Interdisciplinary cooperation is particularly crucial in the fast-evolving fields of medicine and healthcare, which are progressively embracing scientific and technological breakthroughs. In this regard, there is a growing interconnection between medical specialties and other fields. Especially for complex patients—often elderly and frail with multiple comorbidities, such as chronic heart failure, atrial fibrillation, and diabetes mellitus—a more integrated, interdisciplinary approach is essential. At the intersection of various medical specialties lie some of the greatest challenges to human health.

Recent advances highlight the role of immunology in understanding disease mechanisms, particularly through the identification of biomarkers, the study of oxidative stress, and the exploration of genetic polymorphisms that contribute to disease susceptibility and progression. These factors are especially relevant in patients with multiple comorbidities, where immune dysregulation, oxidative damage, and genetic diversity may intersect and drive complex clinical outcomes.

Given the speed at which medical knowledge is growing, an interdisciplinary medical team—comprising experts in immunology, cardiology, endocrinology, genetics, and beyond—is becoming increasingly important for comprehensive patient care and research innovation.

We invite original research articles, comprehensive reviews, and case reports that address these critical interdisciplinary concerns within immunology. We particularly encourage submissions that offer:

Novel biomarkers for diagnosis, prognosis, and therapeutic monitoring of chronic and comorbid conditions

Insights into the interplay between oxidative stress and immune function in complex patient populations

The impact of genetic polymorphisms on immune responses and clinical outcomes, particularly in chronic heart failure, atrial fibrillation, and diabetes mellitus

Interdisciplinary approaches to patient management and translational research

Innovative models or case studies highlighting the importance of cross-disciplinary collaboration in healthcare

This Research Topic aims to foster cross-disciplinary dialogue and set the stage for future collaborative innovation in immunology and clinical practice.

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Interdisciplinarity in the Internal Medicine from Basic Investigations to the Molecular Analysis