Protein folding and misfolding are pivotal processes that have profound implications for cellular function. Protein misfolding is associated with a multitude of diseases, such as Alzheimer's and Parkinson's, making the understanding of folding dynamics essential, particularly in relation to how co-solutes affect protein behavior. Contemporary research delves into these dynamics, providing crucial insights into the molecular mechanisms that underlie protein function and symptomatology. Despite progress, significant challenges persist in effectively capturing the intricate complexities of protein folding and misfolding dynamics, especially in living systems or under diverse physiological conditions. This presents an ongoing need for innovative methodologies and a deeper exploration to bridge existing knowledge gaps.

This Research Topic aims to collect pioneering research and expert reviews to confront the current challenges in the study of protein folding-misfolding dynamics. By introducing innovative methodologies, this collection seeks to advance our understanding of these complex processes. Achieving this will not only elucidate fundamental aspects of protein function but also support the development of novel therapeutic strategies, contributing significantly to the broader field of molecular biology. A diverse array of studies focusing on the kinetic aspects of aggregation, the engineering of co-solutes, protein-drug interactions, and protein-protein interactions is encouraged to enrich and expand the scope of this collection.

To gather further insights into the dynamics and complexities of protein folding in various physiological conditions, this Research Topic invites articles addressing, but not limited to, the following themes:

- Aggregation kinetics and the effect of co-solutes
- Co-solute engineering for therapeutic interventions
- Mechanisms of protein-drug interactions
- Protein-protein interactions and their biological implications
- Innovative techniques in studying protein folding in vivo and in vitro

We welcome contributions that encompass experimental studies, theoretical analyses, and comprehensive reviews to enhance the collective understanding of these pivotal biological processes.

Are you interested in contributing a manuscript to this Research Topic?

Unfolding the Complexity: Dynamics of Protein Folding, Misfolding, and the Role of Co-solutes