It has been shown that synaptic vesicles are organized into various structural and functional pools, which are selectively accessible under different states of activity in the presynaptic terminal. However, there is a surfeit of information linking the functional and structural information which has been accumulated. In this Research Topic of Frontiers, we would like to exemplify the features of these activity-dependent and structural pools, and attempt to generate a consensus on their role in synaptic transmission. E.g., what is the role and reason for segregation of the mini pool of SVs? Why does the functionally-inert reserve pool exist? What is the synaptic consequence of releasing the asynchronous pool? Can SV pools of differing neuronal types be classified? It is our hope that the contributions to this Research Topic will attempt to clarify these points, and generate elegant new questions regarding synaptic vesicle pool organization and function.
It has been shown that synaptic vesicles are organized into various structural and functional pools, which are selectively accessible under different states of activity in the presynaptic terminal. However, there is a surfeit of information linking the functional and structural information which has been accumulated. In this Research Topic of Frontiers, we would like to exemplify the features of these activity-dependent and structural pools, and attempt to generate a consensus on their role in synaptic transmission. E.g., what is the role and reason for segregation of the mini pool of SVs? Why does the functionally-inert reserve pool exist? What is the synaptic consequence of releasing the asynchronous pool? Can SV pools of differing neuronal types be classified? It is our hope that the contributions to this Research Topic will attempt to clarify these points, and generate elegant new questions regarding synaptic vesicle pool organization and function.
