Klinefelter Syndrome, a chromosomal disorder defined by an additional X chromosome in males (47,XXY), affects about 1 in every 500 to 1,000 male births. Despite its prevalence, the condition often goes underdiagnosed and its surgical implications widely misunderstood. This Research Topic seeks to address the various surgical dimensions involved in managing Klinefelter Syndrome, including fertility preservation, cancer risk, and operative risks. The discussion extends to overarching health consequences that impact these patients, underlying gaps and opportunities for enhanced surgical approaches.

This Research Topic aims to explore the surgical treatment of Klinefelter Syndrome with specific focus on fertility and cancer. It seeks to understand the effectiveness of contemporary surgical methods like microdissection testicular sperm extraction (micro-TESE) in enhancing reproductive outcomes. Moreover, it aims to address the pressing need for refined oncological strategies tailored to the heightened risk profiles for malignancies in Klinefelter Syndrome, such as breast cancer and germ cell tumors. In exploring these issues, the goal is to provide a clearer roadmap for managing these complex cases.

To gather further insights on these critical areas, we welcome articles that detail, but are not limited to, the following themes:

- Innovations in fertility surgeries and hormonal treatments in Klinefelter Syndrome patients
- Oncological risk assessment and surgical interventions in Klinefelter Syndrome
- Perioperative risk management for Klinefelter Syndrome patients with comorbid conditions such as osteoporosis and cardiovascular diseases
- Surgical and non-surgical approaches for managing gynecomastia and other physical manifestations of Klinefelter Syndrome
- Cross-disciplinary strategies for improving overall health outcomes in Klinefelter Syndrome

We encourage contributions that explore the intersections of urology, oncology, endocrinology, and surgical practice, to aid in creating more cohesive and effective healthcare protocols for individuals diagnosed with Klinefelter Syndrome.

Are you interested in contributing a manuscript to this Research Topic?

Surgical Management of Klinefelter Syndrome: Addressing Fertility, Cancer Risks, and Perioperative Challanges