Frontiers in Genetics is delighted to present the ‘Reviews in Genetics of Common and Rare Diseases’ article collection.

This Research Topic aims to publish high-quality scholarly review papers on recent progress, challenges, and outstanding questions surrounding the genetics and genomics of common and rare diseases. To advance our understanding of disease biology and therapeutic strategies, reviews will tackle emergent topics that have not been reviewed in the recent literature and critically synthesize current genetic knowledge, mechanistic insights achieved through experimental approaches, and emerging computational tools. Furthermore, the collection seeks to highlight significant knowledge gaps and propose directions for future research that will help translate genetic findings into therapeutic innovation and clinical practice improvements.

To gather further insights in our understanding of genetic contributions to common and rare diseases, we welcome review articles addressing, but not limited to, the following themes:

• Multi-omic approaches to advance knowledge of disease pathophysiology and/or identify disease-relevant biomarkers
• Computational methodologies to advance variant interpretation and analysis of genetic data, i.e. artificial intelligence and big data science in both coding and non-coding regions of the genome
• Lessons learned from study of human populations with diverse ancestry
• Recent exemplars of pleiotropic disease, and strategies to understand gene-phenotype relationships and clinical variability
• Cutting edge in silico, in vitro and in vivo model systems that have aided in disease gene discovery, mechanistic understanding and therapeutic development in human genetic disease.
• Multidisciplinary paradigms to identify therapeutic targets and advance drug development in rare and common human genetic disease

The Reviews in Genetics of Common and Rare Diseases collection ***will only*** welcome full-length, mini, or systematic review papers.

New articles will be added to this collection as they are published. All other article types (e.g. case report, original research, and methods) are out of scope and will be rejected or transferred out of this Research Topic.

Are you interested in contributing a manuscript to this Research Topic?

Reviews In Genetics of Common and Rare Diseases