Biofilms are surface-associated microbial communities embedded in a self-produced extracellular matrix. This mode of growth confers increased tolerance to antimicrobials and immune responses, contributing to the persistence of infections, particularly on medical devices. Their resilience complicates treatment and underscores the need for targeted antibiofilm strategies. Their presence is closely linked to chronic infections, increased resistance to antimicrobial agents, and a significant clinical burden. Biofilms are frequently associated with chronic and device-related infections, where standard antimicrobial therapies often fail. Their presence significantly increases treatment complexity, healthcare costs, and patient morbidity. Therefore, understanding and overcoming biofilm-associated infections have become a priority in infectious disease research, with significant implications for public health and patient care.

This article collection focuses on innovative antibiofilm strategies and their transformative potential for managing infectious diseases. Focusing on the prevention, inhibition, and disruption of microbial biofilms, the collection highlights novel research into compounds, therapeutic approaches, diagnostics, and mechanisms of biofilm physiology. It invites contributions on the molecular characterization of biofilm formation, advances in detection technologies, and evaluations of existing and emerging antibiofilm strategies. By collating work from laboratory studies, clinical investigations, and interdisciplinary collaborations, this collection aims to catalyze progress in understanding and combating biofilm-mediated infections, ultimately improving treatment outcomes and informing the future of infection control.

We welcome articles addressing, but not limited to, the following themes:

· Novel small-molecule inhibitors targeting biofilm formation in clinically relevant pathogens

· Mechanistic studies on biofilm resistance to conventional antibiotics and antifungals

· Evaluations of surface modifications and medical device coatings for biofilm prevention

· Innovative approaches to disrupt or eradicate mature biofilms on indwelling devices

· The role of host immune responses in biofilm-associated infections

· Diagnostic technologies for early detection and monitoring of microbial biofilms

· Synergistic combinatorial therapies involving antibiofilm agents and antimicrobials

· Quorum-sensing inhibitors and their impact on biofilm dynamics

· Natural product-derived antibiofilm compounds and their clinical potential

· Reviews on regulatory pathways and signaling involved in biofilm development

Are you interested in contributing a manuscript to this Research Topic?

Innovative Antibiofilm Strategies: Advancing the Management of Microbial Biofilm Infections