In the realm of cancer research, immune cell dynamics within gastrointestinal cancers have garnered significant attention. Suppressive immune cells such as myeloid cells and regulatory T cells play a pivotal role in manipulating immune responses, thereby influencing cancer progression and treatment outcomes. These immune cells can diminish the effectiveness of therapeutic interventions by promoting immune evasion and resistance to standard cancer treatments. Though substantial knowledge has been gathered regarding their general functions, the intricate signaling pathways and specific interactions driving these processes demand further exploration. Recent studies have started to unravel these complex networks, offering a glimpse into the profound impact of these suppressive cells on cancer progression.

This Research Topic aims to delve into the complex roles and mechanisms of suppressive immune cells within gastrointestinal cancers. The primary goal is to elucidate how these immune cells modulate responses to cancer therapy and contribute to tumor growth and immune evasion. By understanding these mechanisms, the research hopes to identify valuable therapeutic targets within these cell populations. The overarching objective is to leverage this knowledge to develop strategies that can overcome the suppressive effects, enhancing treatment efficacy and improving patient outcomes.

To gather further insights into the immune aspects of gastrointestinal cancers, we welcome articles addressing, but not limited to, the following themes:
• The roles and interactions of myeloid-derived suppressor cells (MDSCs) with other immune cells.
• Mechanisms of immune suppression facilitated by regulatory T cells and their therapeutic relevance.
• Novel therapeutic strategies targeting suppressive immune cells to boost anti-cancer immune responses.
• The application of advanced techniques, such as immunoprofiling, to study these immune cells in gastrointestinal cancers.
• Translational research linking laboratory findings to clinical applications, aiming to implement new strategies in clinical trials.

By focusing specifically on suppressive immune cells and their potential as therapeutic targets, this Research Topic seeks to provide new insights into overcoming immune regulation issues in gastrointestinal cancers, leading to the development of more effective cancer therapies. Articles may include original research, reviews, perspectives, and clinical studies contributing to this vibrant and essential field.

Are you interested in contributing a manuscript to this Research Topic?

Targeting Immune Suppression in Gastrointestinal Cancers: Unveiling Mechanisms and Therapeutic Potential