Recent advances in multi-omics technologies have revolutionized the understanding of tumor biology and inflammatory diseases. By integrating transcriptomics, proteomics, and metabolomics, researchers can acquire a comprehensive molecular landscape of disease states, revealing intricate regulatory networks and identifying potential diagnostic and therapeutic targets. Transcriptomics provides insights into gene expression changes, while proteomics elucidates protein abundance and modifications, and metabolomics reflects alterations in metabolic pathways. Combining these approaches enhances the sensitivity and specificity of biomarker discovery for tumor and inflammatory conditions. Despite significant progress, translating multi-omics data into clinical practice for diagnosis, prognosis, and therapy remains a challenge, requiring standardized workflows, robust validation, and clinical trials. A concerted effort across disciplines and a multidisciplinary platform are essential to accelerate the development of reliable, robust, and actionable biomarkers that can improve patient outcomes and enable personalized medicine.

This thematic collection aims to showcase recent advances in the development of diagnostic and therapeutic biomarkers for tumors and inflammatory diseases through integrated multi-omics approaches, including transcriptomics, proteomics, and metabolomics, fostering collaboration and innovation in precision medicine.

The specific scope includes:

1. Multi-omics integration for biomarker discovery in tumors and inflammatory diseases.

2. Mechanistic insights into tumor and inflammation biology through multi-omics analysis.

3. Development and validation of multi-omics-based diagnostic tools and panels.

4. Clinical translation of multi-omics biomarkers: from bench to bedside.

5. Methodological advances in multi-omics data analysis and integration

6. Case studies and longitudinal studies employing multi-omics for disease monitoring

We encourage the active participation of experts and scholars to collaboratively advance the development of this field.

Please Note: Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.

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Development of Diagnostic and Therapeutic Biomarkers for Tumors and Inflammation Based on Multi-omics Approaches Including Transcriptomics, Proteomics, and Metabolomics