Background: comorbidities represent a complex group of conditions that affect the proper development and functioning of the nervous system. These disorders tend have a heterogenous genetic etiology and marked clinical variability, but also exert a substantial burden on society. Identification of the underlying genetic component to disease has grown exponentially in the last decade, but not all individuals receive a diagnosis. However, individuals who do receive a diagnosis still lack optimal treatment and management options due to deficient insights into the mechanism of disease. Therefore, understanding the phenotypic, genetic, and mechanistic underpinnings of these disorders is crucial for developing targeted interventions and improving the lives of affected individuals.

The goal of this Research Topic is to explore the genetic abnormalities and mechanisms underlying neurodevelopmental disorders and provide insights into their diagnosis, management, and treatment. By bringing together multidisciplinary research, we aim to capture the application of new technology and/or methods for the diagnosis of neurodevelopmental disorders, atypical presentation of disease or phenotypic expansion, and insights into mechanism of disease and altered molecular pathways.

We invite researchers and clinicians to contribute to this Research Topic by submitting manuscripts that explore various aspects of phenotypic variability, genetic characterization, and assessment of mechanistic pathways in neurodevelopmental disorders. Topics of interest include, but are not limited to:

• Atypical presentation of known genetic disorders or phenotypic expansion of disease.

• Identification and characterization of genetic abnormalities related neurodevelopmental disorders through new technology and/or technology improvements.

• Investigation of underlying molecular and cellular mechanisms impacting brain development and function.

• Animal models and experimental approaches to studying neurodevelopmental disorders.

• Biomarkers and diagnostic tools for early identification and intervention.

• Therapeutic strategies and interventions targeting specific molecular pathways.

Do not miss the chance to make your manuscript contribution and showcase your research alongside the research of other outstanding colleagues. Register your interest in the link below so our Topic Editors can make sure to extend deadlines for your submission if needed: Participate in this topic

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Genetics and mechanisms of neurodevelopmental disorders Volume II