Carbohydrate metabolism is central to energy production and regulation in the body, playing a vital role in maintaining metabolic homeostasis. Variations in carbohydrate metabolism can have profound effects on health, influencing conditions ranging from metabolic disorders such as diabetes mellitus and metabolic syndrome to cardiovascular diseases and obesity. Additionally, disturbances in carbohydrate metabolism are implicated in numerous other pathological conditions. Understanding the complexity of carbohydrate metabolic pathways is crucial for enhancing health outcomes and developing effective treatments.

Metabolomics, a comprehensive 'omics' technology, provides a powerful means to explore the intricate metabolite networks and their dynamics underpinning carbohydrate metabolism. This approach enables a systems-level understanding of both normal physiological processes and pathophysiological states, leading to the discovery of novel biomarkers and therapeutic targets. Concurrently, nutrition is an essential modulator of carbohydrate metabolism, affecting enzymatic activities, metabolic pathways, and overall health status.

This Research Topic aims to expand the boundaries of current research by focusing on several key areas of carbohydrate metabolism in both health and disease contexts:
• Broad Examination of Carbohydrate Metabolic Pathways: Investigate the physiological roles and regulatory mechanisms of carbohydrate metabolism under healthy conditions and how they are affected during disease states.
• Integration of Multi-Omics Approaches: Leverage metabolomics in conjunction with genomics, proteomics, and lipidomics to deepen our understanding of the complex interactions and regulatory networks involved in carbohydrate metabolism.
• Advancements in Metabolomics Technologies: Highlight the application of cutting-edge techniques such as advanced mass spectrometry and metabolic flux analysis to unearth new insights into metabolic functions and dysfunctions.
• Nutritional Influences on Carbohydrate Metabolism: Explore the impact of diet and nutrition on metabolic pathways, focusing on how dietary components modulate carbohydrate metabolism and contribute to disease prevention and management.
• Personalized Nutrition and Health: Emphasize the potential of metabolomic profiling in tailoring nutritional interventions and therapeutic strategies to individual metabolic profiles and health conditions.
• Translational Research Focus: Bridge the gap between basic research and clinical application by translating metabolomic and nutritional insights into actionable strategies for healthcare providers.
• Molecular Mechanisms and Disease Links: Explore the molecular underpinnings of altered carbohydrate metabolism, including the roles of mitochondrial dysfunction, oxidative stress, and inflammation, with a focus on modifiable dietary factors.

We invite original research, reviews, and methodological papers that delve into the latest advancements in metabolomics and nutrition research related to carbohydrate metabolism. By fostering innovative approaches and promoting cross-disciplinary collaboration, this Research Topic seeks to enhance our understanding of carbohydrate metabolism in health and disease, ultimately guiding the development of more effective diagnostic tools and personalized nutritional and therapeutic strategies.

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Advancing Carbohydrate Metabolism Physiology and Pathophysiology Through Metabolomics