Cardiometabolic diseases such as obesity, type 2 diabetes, metabolic-associated fatty liver disease (MAFLD), and cardiovascular disorders are major public health challenges worldwide. These disorders often coexist and share common pathophysiological mechanisms, including insulin resistance, systemic low-grade inflammation, oxidative stress, and endocrine-metabolic dysfunction. In recent years, there has been growing interest in exploring how nutritional and lifestyle interventions can modulate these mechanisms and improve clinical outcomes. Among them, the Mediterranean diet has shown particular promise in reducing inflammation and improving metabolic health.

The aim of this Research Topic is to explore the complex interplay between metabolic and inflammatory pathways in the development and progression of cardiometabolic diseases, with a special emphasis on translational research and clinical relevance. We particularly welcome studies that assess how diet, physical activity, pharmacological treatments, or combined interventions can influence endocrine function, inflammation, and organ-specific health, especially the liver and cardiovascular systems.

We welcome original research articles, clinical trials, systematic reviews, and mini-reviews that address, but are not limited to, the following themes:

• Effects of dietary patterns (e.g., Mediterranean diet, plant-based diets, ultra-processed food consumption) on metabolic and inflammatory markers.

• Mechanistic insights into the role of chronic inflammation in MAFLD, insulin resistance, and organ dysfunction.

• The impact of nutritional and lifestyle interventions on endocrine pathways and cardiometabolic outcomes.

• Multi-omics approaches (metabolomics, proteomics, transcriptomics, gut microbiome) in the identification of novel biomarkers or therapeutic targets.

• Clinical or translational research on non-invasive tools for monitoring disease progression and treatment response.

• Gender-specific or age-related differences in metabolic and inflammatory responses.

This collection of articles seeks to bridge basic science and clinical practice by highlighting research that can guide precision nutrition and personalized therapeutic approaches in the field of endocrinology and metabolism. We particularly encourage contributions from multidisciplinary teams and international collaborations that combine clinical data with molecular, nutritional, and physiological insights.

Are you interested in contributing a manuscript to this Research Topic?

Metabolic and Inflammatory Pathways in Cardiometabolic Diseases: From Nutritional Interventions to Clinical Applications