Clinical trials are the cornerstone of evidence-based practice in cardiovascular medicine. As the field continues its rapid evolution—spanning from molecular discoveries to cutting-edge device therapies and population health interventions—rigorous prospective studies remain indispensable for validating new treatments and transforming patient care.

Many areas within cardiovascular medicine offer exciting opportunities for impactful clinical trials to inform best practices, especially among populations with diverse comorbidities or those traditionally underrepresented in research. As innovative therapies and technologies continue to emerge, new questions about efficacy, safety, and real-world implementation provide valuable avenues for advancing patient care and driving scientific progress.

This Research Topic aims to create a comprehensive, multidisciplinary platform dedicated to original clinical trials that address the most pressing challenges and novel developments across the full spectrum of cardiovascular medicine. By curating high-impact clinical studies, we seek to accelerate the translation of scientific advances into practical solutions that improve outcomes for patients worldwide.

To ensure clarity and impact, this Research Topic will focus on clinical trials (randomized, non-randomized, pragmatic, adaptive, or pilot studies) with clear clinical applicability and relevance to current cardiovascular practice. Manuscripts may cover, but are not limited to, the following key themes:

o New pharmacological or interventional therapies for cardiovascular conditions
o Comparative effectiveness or implementation studies of established treatments
o Novel prevention strategies or risk factor interventions
o Trials addressing sex, gender, and population disparities in cardiovascular disease
o Investigations of digital health in cardiovascular medicine
o Clinical studies of pediatric, geriatric, or special cardiovascular populations
o Innovative trial design, endpoints, or statistical methods relevant to cardiovascular research
o Trials supporting the UN’s Sustainable Development Goal (SDG), notably SDG#3: Ensure healthy lives and promote well-being for all at all ages.

This Research Topic is open for Clinical Trial and Study Protocol related to clinical studies article types only.

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Clinical Trials in Cardiovascular Medicine: 2025