To be held in Torino in September 2025, the Annual Meeting of the Italian Society of Physiology will celebrate its 75th anniversary with a Joint Symposium with the Slovenian Physiological Society (https://sif2025.azuleon.org/). The congress will highlight cutting-edge research across physiological domains, from molecular mechanisms to clinical translation. Contributions will cover calcium signaling in health and disease, cardiometabolic dysfunction, and the heart-brain axis, alongside topics such as astrocyte diversity, cerebellar circuit dysfunction in neurodevelopmental disorders, and cancer physiology at the interface of cell signaling and microenvironment. Keynote lectures will address cardiovascular protection by remote ischemic conditioning, highlighting the roles of neural and humoral mechanisms, nanoscale cAMP signaling in cardiomyocytes, and neuromodulation therapies restoring function after spinal cord injury. Dedicated sessions will reflect on major electrophysiological discoveries and on the creative role of serendipity in science.

This Research Topic will welcome studies that bridge basic and translational physiology, aiming to inspire innovation and interdisciplinary collaboration for advancing human health.

Despite major advances in physiology, many fundamental mechanisms underlying human health and disease remain incompletely understood. Bridging the gap between molecular insights and therapeutic innovation requires integrated approaches, combining basic, translational, and clinical research. The 75th Annual Meeting of the Italian Society of Physiology, jointly organized with the Slovenian Physiological Society, will provide a platform to address this challenge by showcasing recent breakthroughs across physiological systems and levels of complexity.

This Research Topic aims to capture the scientific breadth of the meeting and foster interdisciplinary dialogue. We welcome original research, reviews, and perspectives that explore how physiological mechanisms—from molecules to systems—can inform novel strategies for diagnosis, treatment, and prevention of disease.

Main areas of interest include, but is not limited to:

• Astrocyte diversity and cerebellar dysfunction in neurodevelopment
• Calcium signaling in health and disease
• Cancer physiology: cell mechanisms and microenvironment
• Cardiometabolic regulation and intercellular communication
• Environmental stressors and endogenous protective pathways
• Heart-brain axis and/or neuromodulation therapies
• Innovations in electrophysiology and nanoscale signaling
• Serendipity in science and its role in physiological discovery

By integrating diverse approaches and linking molecular mechanisms to whole-body function, this collection aims to translate physiological research into clinically relevant insights and innovative therapeutic strategies.

We welcome the submission of original research articles, reviews, mini-reviews, and perspectives that explore physiological mechanisms with or without translational potential. Topics may span molecular, cellular, systems, and integrative physiology, including interdisciplinary approaches.

Although not mandatory, we encourage authors to submit a short manuscript summary (abstract-like) in advance. This summary does not need to match the final manuscript abstract but will help assess relevance and plan the collection.

Are you interested in contributing a manuscript to this Research Topic?

75th Annual Meeting of the Italian Society of Physiology: Innovations and Emerging Directions in Physiological Research