The rapidly evolving field of biomaterials has been significantly augmented by advances in hydrogels derived from natural polymers. These hydrogels possess biomimetic and bioactive properties that bridge the gap between synthetic materials and biological tissues, thus offering great promise for regenerative applications. Their innate ability to mimic the extracellular matrix and provide a conducive environment for cellular activities makes them ideal candidates for developing innovative biomaterials. However, despite their potential, traditional materials often face challenges in replicating the complexity of biological interfaces, prompting researchers to explore novel natural polymer-based hydrogels. Recent investigations have aimed at enhancing critical attributes such as adhesion, self-healing capabilities, stimuli-responsiveness, injectability, antimicrobial properties, and angiogenesis support, all of which are crucial for their broader application.

The focus of this Research Topic is on leveraging natural polymer hydrogels as functional biomaterials to propel advances in regenerative medicine. The exploration centers around understanding the gelation mechanisms involved in both physically and chemically cross-linked hydrogels and deciphering the structure-property relationships that influence their functional behavior. Moreover, there is a strong interest in integrating these hydrogels with bioactive ceramics, such as hydroxyapatite, tri-calcium phosphates, and bioglasses, which hold the potential to elevate their performance by imparting additional structural and functional benefits. Such integrations are invaluable for creating biomaterials that not only replicate but also enhance the natural tissue environment, thus facilitating regeneration and repair.

Research in this area is crucial not only for biomedical applications but also for expanding our understanding of hydrogels as versatile materials in other fields such as pharmaceuticals, cosmetics, and environmental science. To foster a comprehensive understanding and advancement of natural polymer hydrogels in the biomaterials domain, we invite contributions that delve into various thematic areas.

We welcome articles that address, but are not limited to, the following themes:
o Innovations in adhesive and self-healing properties of biomimetic hydrogels
o Development of stimuli-responsive and injectable hydrogels for versatile applications
o Exploration of antimicrobial properties and their impact on biocompatibility
o Synergistic effects of incorporating bioactive ceramics into natural polymer hydrogels
o Advanced development and characterization techniques for novel hydrogels
o In-depth analysis of gelation mechanisms and elucidation of structure-property relationships

Contributions in the form of Original Research, Review, and Perspective articles are encouraged to further the knowledge base and showcase the latest advancements in this vibrant area of biomaterials research.

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Functional Hydrogels as Biomaterials: Advancing Natural Polymer Applications