The field of cardiology is increasingly recognizing the importance of sex differences as a critical factor in cardiovascular health, influencing both the biological understanding and clinical management of heart diseases. Despite evident sex disparities in cardiovascular disease manifestations and outcomes, much of the foundational research has predominantly focused on male subjects. This oversight obscures the nuanced understanding necessary for developing effective sex-specific diagnostic, preventive, and therapeutic interventions. To address these challenges, this Research Topic is dedicated to delving into the sex differences in cardiology by leveraging insights from basic research, translational studies, and clinical practices, with the overarching aim of supporting personalized medicine.

This Research Topic aims to enhance our comprehension of sex differences in cardiology by exploring their molecular foundations and assessing their impacts on translational and clinical research. By highlighting new clinical insights attributable to sex-specific mechanisms, we aim to integrate a comprehensive sex-specific approach across all aspects of cardiovascular research and care. The goal is to promote improved patient outcomes by fostering a nuanced understanding of these differences in the context of cardiovascular health.

Our scope encompasses a range of segments, from basic to clinical research, and focuses on:

• Investigating molecular and cellular mechanisms underlying sex differences in cardiovascular biology.
• Assessing the role of sex and gonadal hormones and sex chromosomes on the cardiovascular system.
• Evaluating sex-specific risk factors, symptoms, and outcomes in diseases such as pulmonary hypertension and coronary artery disease.
• Exploring the effects of emerging cardiovascular therapies across different sexes.
• Evaluation of the effects of novel cardiovascular therapies in pre- and postmenopausal women.
• Use of animal models to investigate sex-specific differences and underlying mechanisms in cardiovascular disease.
• Developing innovative methodologies for studying sex differences.

To gather further insights into the boundaries of sex differences in cardiology, we welcome manuscripts addressing, but not limited to, the following themes:

• Molecular and cellular mechanisms underpinning sex differences.
• Influence of hormones on cardiovascular health.
• Efficacy and safety of cardiovascular therapies in different sexes.
• Sex-specific risk factors and treatment responses.
• Incorporating sex differences into clinical guidelines.
• Innovative methodologies and technologies, including the use of AI and big data, to study sex disparities.

Contributions from varied cardiovascular research fields are invited, including original research articles, reviews, clinical studies, and innovative perspectives that complement the outlined themes. Through a multifaceted discourse on sex differences in cardiology, this Research Topic aims to further a refined understanding that informs and transforms cardiac care tailored to gender-specific needs.

Are you interested in contributing a manuscript to this Research Topic?

Unveiling Sex Differences in Cardiology: Integrative Research and Clinical Implications

Topic Coordinator