The multidisciplinary area of integrative chemical biology and molecular biosciences uses concepts from biology, chemistry, and computer sciences to comprehend biological processes at the molecular level. This integrated method has completely changed the way scientists study intricate biological processes. With roots in organic chemistry, biochemistry, pharmacology, molecular biology, and biophysics, this field is naturally multidisciplinary, examining the functions of tiny and macromolecules as well as their interactions inside cells and animals.
On the other hand, molecular biosciences integrate methods from systems biology, proteomics, enzymology, genomics, and structural biology to explore biomolecular structure, function, regulation, and interaction. Chemical proteomics, computational chemistry, drug discovery, precision medicine, multi-omics integration, elucidation of disease mechanisms, biomarker development.
This integrative approach fosters the rational design of interventions in health and disease, enables innovative synthetic biology tools, It is particularly impactful in areas such as cancer biology, neurobiology, infectious diseases, and immunology.

Despite immense progress in molecular biosciences and chemical biology, a critical gap remains in our ability to fully understand and manipulate complex biological systems at the molecular level with precision, while chemical biology tends to focus on isolated molecular interactions or probe development. What’s lacking is a comprehensive, integrative approach that combines real-time, spatially resolved, and functionally relevant insights into biological phenomena of limited spatiotemporal resolution, inadequate integration, and fragmented methodologies.

To overcome these challenges, an integrative approach combining synthetic chemistry, chemical probe design, structural biology, systems biology, and advanced imaging is needed. This unified framework can allow design of precision chemical probes, link structure to function, map dynamic protein–protein and protein–ligand interactions, visualize molecular processes in real time, and integrate large-scale omics data. Several recent breakthroughs highlight the feasibility and potential of this integrative strategy bio-orthogonal click chemistry, Proteolysis-targeting chimeras (PROTACs), Single-cell proteomics, and spatial transcriptomics.

This Research Topic aims to showcase cutting-edge research and reviews at the intersection of chemical biology and molecular biosciences, highlighting how integrative approaches can unravel complex biological systems and accelerate discoveries in human health, disease, and therapeutic development.
We welcome contributions that combine chemical tools, molecular insights, and biological applications to offer a comprehensive understanding of biological mechanisms, molecular interactions, and structure–function relationships. The goal is to bridge traditional boundaries and encourage interdisciplinary work that applies chemistry-driven methods to solve fundamental and translational problems in biology.

Areas of interest include, but are not limited to:

•Drug discovery / Medicinal chemistry
•Chemical biology
•Synthetic biology
•Biomolecular interactions / Structural biology
•Metabolomics / Systems biology
•Enzymology / Catalysis
•Computational chemistry / Molecular modeling

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Bridging Disciplines: Advancing Chemical Biology and Molecular Biosciences through Integrative Strategies