After the success of our Research Topic "The Insights of Multi-Omics into the Microenvironment After Tumor Metastasis: A Paradigm Shift in Molecular Targeting Modeling and Immunotherapy for Advanced Cancer Patients", we are pleased to launch a second volume of this collection, which will bring together recent developments in the field.

Understanding the complex interplay within the tumor microenvironment post-metastasis through multi-omics is essential for revolutionizing treatment approaches in advanced cancer. The integration of genomic, epigenomic, proteomic, and metabolomic data offers a panoramic view of the biological mechanisms that drive metastasis and therapy resistance. This holistic perspective helps in identifying molecular signatures and metabolic changes, which are crucial for developing precision medicine strategies. Such comprehensive analyses potentially lead to innovative molecular targeting models and immunotherapeutic approaches, aiming to dramatically alter the therapeutic landscape for advanced cancer patients.

This Research Topic aims to explore the transformative potential of multi-omics to enhance the understanding and treatment of advanced cancer. By dissecting the molecular intricacies and immune interactions within the tumor microenvironment, the goal is to tailor therapy approaches that target not just tumor cells but also their surroundings. This strategy intends to boost immunotherapy effectiveness, increase patient survival rates, and improve quality of life. Driving this shift toward customized treatments reflects an emerging frontier in oncology, promising new hope and better outcomes for patients facing advanced cancers.

To gather further insights into the intersection of immunotherapy, multi-omics, and tumor microenvironments, we welcome articles addressing, but not limited to, the following themes:
o High-quality literature reviews focusing on immunotherapy applications in tumor treatments.
o Studies exploring the dynamic changes in the tumor microenvironment post-metastasis and their implications on tumor progression and immune response.
o Research on refining immunotherapy strategies through multi-omics data to improve therapeutic outcomes.
o Detailed analysis of the molecular mechanisms driving tumor metastasis, including gene expression alterations and metabolic shifts.
o Identification and validation of biomarkers for predicting metastasis and therapeutic responses in personalized medicine approaches.
o Assessments of how multi-omics research can be integrated into clinical settings to enhance treatment protocols for advanced cancer patients.
o Investigations into new therapeutic models based on multi-omics findings to overcome tumor diversity and drug resistance.

Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent clinical or patient cohort, or biological validation in vitro or in vivo, which are not based on public databases) are not suitable for publication in this journal.

Are you interested in contributing a manuscript to this Research Topic?

The Insights of Multi-Omics into the Microenvironment After Tumor Metastasis: A Paradigm Shift in Molecular Targeting Modeling and Immunotherapy for Advanced Cancer Patients - Vol II