Lipid metabolism is a vital process in cell homeostasis and survival. It involves lipid biosynthesis and storage, energy production, membrane formation, and hormone synthesis, among others. However, tumor cells remodel themselves due to constant oncogenic events and metabolic factors of the tumor microenvironment to fuel the complex physiological processes that sustain uncontrolled growth and proliferation, such as to meet increased energy demands obtained from lipids and to enhance cancer progression. Over recent decades, non-coding RNAs (ncRNAs) have transitioned from being perceived as genomic 'junk' to being recognized as master regulators of gene expression. These ncRNAs are now known to participate in several significant biological processes, including alterations in lipid metabolism and metabolic reprogramming, yet their precise role in these modifications within tumor cells, especially concerning lipid utilization, remains unclear.

This Research Topic aims to elucidate the intricate biological role of ncRNAs in lipid metabolism and metabolic reprogramming, and their regulation and behavior as key molecules for malignant transformation in various types of cancer. Additionally, this Research Topic strives to uncover potential new biomarkers and therapeutic targets, promising profound clinical implications for ncRNAs as regulators of lipid metabolism in cancer. We aim to collect various innovative and pioneering studies with different observational, experimental, and in silico prediction approaches that highlight the biological importance and clinical implications of ncRNAs in lipid metabolic reprogramming, both in solid and non-solid tumors.

We welcome submissions of original research, review, mini review, systematic review, method, clinical trial, general commentary, or perspective articles. We encourage submissions that broaden the landscape of under-reported ncRNAs in an emerging hallmark of cancer to identify new biomarkers or therapeutic targets for clinical research in different malignant neoplasms. Key themes will include:

- Endocrine, metabolic, nutrient, and hormonal alterations

- Cholesterol and triglycerides metabolism

- Overweight and obesity

- Solid and non-solid tumors

- Tumor microenvironment

- Diagnostic or prognostic biomarkers

- Possible treatments

Ultimately, the scope of this Research Topic offers researchers insights into new hypotheses, cultivating a meaningful landscape within various medical, clinical, academic, and basic scientific areas.

Are you interested in contributing a manuscript to this Research Topic?

Role of Non-coding RNAs in Lipid Metabolism and Metabolic Reprogramming in Cancer