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Synthetic Biology-Guided Metabolic Engineering

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Synthetic biology aims at making biology an engineering discipline by turning molecular and cellular behaviours into a more controllable, standardized and predictable set of features. Metabolic engineering seeks to reprogram the metabolic wiring in a cell in order to expand, improve or modify its natural ...

Synthetic biology aims at making biology an engineering discipline by turning molecular and cellular behaviours into a more controllable, standardized and predictable set of features. Metabolic engineering seeks to reprogram the metabolic wiring in a cell in order to expand, improve or modify its natural properties for useful purposes such as , for example, maximizing the production of a target compound or degrading a pollutant in an efficient way. In the last few years, a steady increase of synthetic biology-inspired approaches for metabolic engineering has enabled researchers in the field to adopt a truly rational methodology to reprogram the cell behavior.

This Research Topic is intended to collect research articles, method articles, technology reports, reviews, mini-reviews, perspective or opinion articles on how the recent technical advances in synthetic biology (such as DNA assembly, genome synthesis, sequencing and NGS, genetic engineering, control theory, metabolic modeling, genome editing, orthogonality and fine control of gene expression), can be used to manipulate the metabolism of target cells in a more efficient, faster and reliable manner.


Keywords: synthetic biology, metabolic engineering, bioproduction, industrial biotechnology, cell factories


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