Female reproductive function is contingent upon the precise orchestration of molecular, cellular, and environmental factors to secure successful oocyte maturation, fertilization, and early embryo development. The developmental competence of oocytes, including meiotic resumption and embryo-supporting capacity, along with the genomic stability of early embryos, are pivotal determinants of female reproductive function. These processes are regulated by epigenetic reprogramming, transcriptional networks, and metabolic homeostasis within the follicular microenvironment. Recent advancements underscore the importance of reproductive niches like follicular fluid and uterine surroundings in preserving gamete and embryo quality. Despite these insights, disruptions due to intrinsic or extrinsic factors can result in reproductive failure, highlighting the need for continued exploration into these pathways for improved reproductive health solutions.

This Research Topic aims to unravel the complex physiological and pathological foundations of female reproductive function. The primary objectives include understanding the disruptions in oocyte maturation and embryo development, elucidating epigenetic and transcriptional regulatory mechanisms, and assessing the follicular and uterine microenvironments' role. The goals extend to evaluating the genomic stability of early embryos and the impact of environmental stressors on reproductive health. Through this exploration, we aspire to unveil innovative strategies that enhance fertility preservation and improve reproductive outcomes.

To gather further insights into this area, focusing on the physiological and pathological foundations of female reproductive function, we welcome articles addressing, but not limited to, the following themes:
• Molecular mechanisms of oocyte maturation and embryo development.
• Epigenetic and transcriptional regulation in gametes and embryos.
• Influence of the follicular microenvironment on oocyte quality.
• Genomic stability and DNA repair during early embryo development.
• Environmental stressors affecting reproductive health.
• Uterine microenvironment’s role in implantation and early pregnancy.

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Physiological and Pathological Foundations of Female Reproductive Function

Topic Coordinator