This Research Topic is the second volume in this series, " Community Series in: Clinical and Genetic Determinants of Diabetes and Complications". Please see volume I here.

Diabetes Mellitus (DM) remains one of the leading causes of death around the world, which leads to a heavy global burden on public health. As predicted by International Diabetes Federation, a 50% increase in the number of patients with DM will be reached by 2030 compared to 366 million in 2011. DM has multiple complications that cause the injury of several organs such as heart and kidneys, leading to a reduction in quality of life and a higher premature mortality rate. For example, diabetic patients have two-fold increased risk for cardiovascular mortality. The pathogenesis of DM is multifactorial, and several clinical risk factors, such as being overweight or obese, have been proposed. But the contributions of several other putative factors on the pathogenesis of DM are still inconclusive. At genetic level, a family history of DM increases DM risk, and more than 500 genetic loci have been found to be associated with DM. However, the genetic determinants of DM complications are less understood. Most importantly, we are far from understanding the complex interaction effects of clinical and genetic factors on DM risk.

In this Research Topic, we hope to create a forum for new insights into understanding the role of clinical and genetic risk factors as well as their potential interaction in the pathogenesis of diabetes and its complications. We welcome submissions of Original research articles, Review articles, Opinions and Perspectives, in the subtopics of the following, but not limited to:

• Clinical risk factors that contribute to the pathogenesis of diabetes
• Clinical risk factors affecting the development of complications in diabetic patients
• Genetic basis of diabetes and its complications
• The role of interaction between clinical and genetic risk factors in diabetes

Are you interested in contributing a manuscript to this Research Topic?

Community Series in: Clinical and Genetic Determinants of Diabetes and Complications - Volume II