This Research Topic is the third edition of the series, previous editions can be found here; Volume I and Volume II : https://www.frontiersin.org/research-topics/44712/drug-metabolism-and-transport-the-frontier-of-personalized-medicine.

There are many unique challenges in personalizing drug therapy. Research on pharmacokinetics and pharmacodynamics of drugs is beneficial to ensure the safety and efficacy of clinical medication. There have been many advances in technology and drug model metrology in drug metabolism and transport studies, but our understanding of the factors that influence drug disposition and efficacy still needs to be refined.

The purpose of this special issue is to report on factors influencing the pharmacokinetics of drugs, such as drug dosage forms, drug-drug interactions, metabolic enzymes, transporters, pharmacogenetic polymorphisms, pharmacomicrobiome, and specific environments, etc. It aims to standardize personalized medicine and promote clinical rational drug use.

This Research Topic will include but is not limited, to reporting:

• Effects of dosage form, dose, and route of administration on pharmacokinetics.

• Pharmacokinetic alterations and mechanisms mediated by drug-drug interactions.

• Mechanism of drug-metabolizing enzyme alterations mediated by external factors, such as high-altitude hypoxia.

• Mechanism of drug transporter changes or gut microbiota mediated by external factors, such as high-altitude hypoxia or antibiotic.

• Effects of gene polymorphisms of drug-metabolizing enzymes on drug action.

• Research methods of intestinal drug transporters.

• Effect of intestinal flora on drug metabolism.

• Discovery of specific probes for drug-metabolizing enzymes.

• Implications of drug interactions mediated by transporters or metabolizing enzymes for precision medicine.

• The utilization of artificial intelligence (AI) and deep learning (DL) in drug metabolism and transport research

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Drug Metabolism and Transport: The Frontier of Personalized Medicine, Volume III