Emerging research highlights the complexities of cardiovascular medicine, particularly regarding the interplay between genetic predispositions, environmental factors, and epigenetic modifications. Recent studies emphasize these interactions' variations between genders, significantly influencing cardiovascular disease onset, progression, and treatment. However, there is still debate about the specific mechanisms involved and gaps in understanding gender-specific responses, necessitating further investigation.

This research topic seeks to deeply investigate the complex nature of gene-environment interactions and their epigenetic foundations in gender-specific cardiovascular conditions. By analyzing these elements, the goal is to advance personalized medical approaches that consider gender differences.

Specific objectives include identifying key genetic factors, assessing environmental impacts, and formulating hypotheses related to gender-specific responses. Contributions are welcome in the form of original research, comprehensive reviews, and insightful commentaries.

This research topic will focus on gender-specific differences in cardiovascular health. Key themes include:

- Epigenetic modifications like DNA methylation in male vs. female cardiovascular conditions.

- Environmental influences (diet, stress) on gene expression by gender.

- Genetic variations contributing to gender-specific cardiovascular pathophysiology.

- Development of gender-differentiated biomarkers for cardiovascular risk.

- Gender-tailored therapeutic strategies stemming from genetic and epigenetic research.

Interdisciplinary approaches combining clinical practice with genetic studies.

By bringing together research that spans genetics, epigenetics, environmental science, and clinical practice, this Research Topic aims to propel forward our understanding of gender disparities in cardiovascular medicine. Through these interdisciplinary efforts, we anticipate the development of more precise and effective prevention, diagnostics, and treatment strategies that acknowledge and harness these crucial differences. We encourage scholars, clinicians, and scientists from diverse fields to contribute their findings and perspectives.

Topic Editor Prof. Rita Del Pinto received research grants from the Eklund Foundation, the Crohn’s and Colitis Foundation.

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Epigenetics and Gene-Environment Interactions in Gender-Specific Cardiovascular Medicine

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