Circadian rhythms are intrinsic 24-hour cycles that govern a wide array of physiological and behavioral processes in almost all living organisms. Driven by a complex interplay of molecular clocks, these rhythms orchestrate critical biological functions such as sleep-wake cycles, hormone secretion, metabolism, immune responses, and cellular repair. Disruption of circadian rhythms, whether through lifestyle factors, environmental cues, or genetic mutations, has been increasingly linked to the pathogenesis of multiple diseases, including metabolic disorders, cardiovascular diseases, cancer, and neurodegenerative conditions.

Recent research highlights how circadian clocks regulate gene expression and cellular signaling pathways, emphasizing their central role in maintaining homeostasis. Understanding the molecular mechanisms underlying circadian regulation provides a promising avenue for developing therapeutic interventions that restore rhythmicity and improve disease outcomes. Chronotherapy, which aligns treatment timing with circadian cycles, has shown potential to enhance efficacy and reduce side effects in cancer and other chronic diseases.

This Research Topic aims to consolidate cutting-edge research exploring the influence of circadian rhythms across diverse biological systems and their contribution to disease development. Studies that integrate molecular, cellular, and systemic perspectives are particularly encouraged, as they provide comprehensive insights into how circadian dysregulation drives pathology.

Key Research Areas Include:

• Molecular mechanisms of circadian clock regulation and their impact on cellular function

• Circadian control of metabolism, immune responses, and hormone signaling

• Links between circadian disruption and chronic diseases, including cancer, diabetes, and neurodegeneration

• Chronotherapy approaches and timing-based interventions for disease management

• Environmental and lifestyle factors influencing circadian homeostasis

By highlighting the interplay between circadian biology and disease, this topic seeks to advance our understanding of temporal regulation in health and pathology, ultimately guiding innovative strategies for prevention, diagnosis, and treatment.

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Circadian Rhythms: Key Regulators of Biological Systems and Disease Pathogenesis