The human body operates through dynamic inter-organ communication, yet perhaps no axis has remained as underexplored and promising as the one connecting the gut microbiota, immune signaling, and ovarian health. Emerging evidence positions the gut-ovary axis as a crucial player in female reproductive biology, with systemic inflammation serving as a potent mediator of ovarian dysfunction.

Dysbiosis, characterized by altered microbial diversity and metabolite imbalances, has been linked to chronic inflammatory states that directly affect ovarian granulosa cells, folliculogenesis, and endocrine homeostasis. Conditions such as polycystic ovary syndrome (PCOS), endometriosis, and premature ovarian insufficiency exhibit mechanistic links to immune dysregulation, metabolic stress, and microbial-derived factors like lipopolysaccharides, bile acids, and short-chain fatty acids.

This special issue invites contributions that explore the biological intersections among gut microbiota, systemic inflammation, and ovarian function. We especially welcome work that bridges:

- Reproductive endocrinology and immunology
- Microbiome research and ovarian cell biology
-Epigenetic and metabolic pathways in granulosa cell regulation
-Fertility implications of systemic immune-microbial interactions
-Therapeutic advances (e.g., probiotics, dietary interventions, microbiota-targeted drugs)

Topics of Interest Include:
· The role of gut-derived metabolites in granulosa cell maturation and apoptosis
· Inflammatory signaling cascades impacting follicular development
· Gut microbiome signatures in different ovarian disorders
· Ovarian tumor susceptibility is associated with systemic inflammation
· Microbiota–endocrine feedback loops in reproductive senescence
· Experimental Models that explore the gut health and reproductive function axis
· Microbiota, influence of endocrine system on reproductive health
· Gut microbiota-reproduction health through nutrition, immunology, and signaling.

Call for Papers:
We prioritize manuscripts that stand in inter- and transdisciplinary research through the application of innovative conceptual frameworks to theoretical models, methodological advancements, and strategic implementations. Submissions that support innovative perspectives that are consistent with the Sustainable Development Goals, with a particular emphasis on the promotion of cross-disciplinary collaboration and the improvement of clinical comprehension of ovarian disorders, are particularly encouraged. We welcome research that advances the field of reproductive medicine through microbiota-based diagnostics and therapeutics, provided such work clearly emphasizes either broad or specific initiatives and addresses existing knowledge gaps concerning the health impacts of ovarian diseases. We seek substantial contributions grounded in original research, systematic reviews, or methodological innovations.

Are you interested in contributing a manuscript to this Research Topic?

The Gut-Ovary-Immune Axis: A Call for Cross-Disciplinary Insights