3D printing has rapidly emerged as a transformative technology within the field of biofabrication, revolutionizing the 3D assembly of functional units for a wide range of biomedical applications. Its versatility makes it a cornerstone in areas such as tissue engineering, drug delivery, and regenerative medicine. In recent years, the integration of artificial intelligence (AI) with additive manufacturing (AM) has opened exciting new possibilities, paving the way for unprecedented levels of design precision, process automation, and functional integration in the development of bioactive systems.

AI-driven approaches empower researchers and engineers to tackle some of the longstanding challenges in biofabrication. By automating complex design tasks and optimizing manufacturing parameters, AI contributes to the creation of highly personalized, efficient, and scalable biomedical constructs. These smart systems go beyond traditional methods, enabling the fabrication of bioactive constructs that closely replicate the structure, complexity, and heterogeneity of native tissues and organs. The synergy between AI and 3D printing also helps overcome bottlenecks related to material compatibility and reproducibility, thereby accelerating clinical translation and wider adoption in personalized medicine.

This Research Topic is dedicated to exploring the transformative impact of AI-enhanced 3D printing technologies in biofabrication for biotechnology applications. The scope of this collection encompasses advances in AI-enabled design methodologies, innovative material development, and the assembly of functional biological entities. By addressing fundamental and applied questions related to the use of AI in biofabrication processes, this Topic aims to stimulate innovation, promote interdisciplinary collaboration, and drive the progression of next-generation healthcare technologies.

Specific areas of interest include, but are not limited to:

• AI and computational design automation for the development and assembly of bioactive 3D constructs
• Cutting-edge bio(material) ink development and characterization for personalized medical devices
• Advanced strategies for drug delivery and therapeutic platforms developed through biofabrication
• Creation and utilization of bio-reinforced and functional composites for medical and biomedical applications
• Biofabrication approaches in regenerative medicine, with an emphasis on the patterning and assembly of bioactive molecules, living cells, and tissues

We invite articles that deepen our understanding of AI-driven biofabrication and inspire innovative solutions for the advancement of biotechnology and regenerative medicine.

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From AI-Enhanced Design to Bio-Reinforced Constructs: Innovations in 3D Printing for Biotechnology