Gastrointestinal (GI) complications are common in patients with Inborn Errors of Immunity (IEI), and include various infections, autoimmune conditions like inflammatory bowel disease (IBD), and cancers. These contribute significantly to the morbidity and overall quality of life of affected individuals. Patients may present with symptoms that mimic other GI diseases, but an accurate diagnosis is often less easy to achieve, and they tend to respond poorly to conventional therapies. Recently, research has increasingly focused on understanding the complex interplay between immune deficiency, mucosal immunity, dysfunction in B cell function, and challenges from microbial agents. Despite advances in this field, significant gaps remain in our understanding of the diagnosis and management of these complications.

This Research Topic aims to consolidate emerging insights into the immunological and molecular foundations of gastrointestinal complications in IEI. Our goal is to create a platform for disseminating innovative diagnostic, management, and therapeutic approaches in this area. By fostering cross-disciplinary collaboration, this initiative seeks to answer specific questions concerning the mechanistic details of immune deficiency-related gut pathologies. It will also evaluate novel therapeutic strategies such as targeted immunomodulation and microbiome-based interventions.

The scope of this Research Topic includes a range of interconnected areas in patients with IEI, such as:

-Molecular pathways linked to the associated gut inflammation, including the role of B-cells, plasma cells, and mucosal IgA responses.
-Autoimmune-mediated gut pathologies, including coeliac-like enteropathy and IBD.
-Infection dynamics from norovirus, Campylobacter, Giardia, Salmonella infection, and other bacterial, viral, or parasitic agents.
-Novel diagnostic and treatment pathways for appropriate, disease-specific management.

Manuscripts discussing lymphoid hyperplasia, malignancy risks, phenotype-genotype correlations, and high-resolution molecular assessments are also welcome. Furthermore, original research articles, reviews, and meta-analyses that advance our understanding of immune dysfunction and its implications for gastrointestinal complications in PIDs are highly encouraged. This Research Topic ultimately aims to propel the development of diagnostics and therapies that enhance patient care and outcomes.

The topic editors declare no conflicts of interest

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Emerging Insights into Gastrointestinal Complications in patients with Inborn Errors of Immunity