The integration of multi-omics and AI-driven approaches represents a cutting-edge frontier in agricultural research, aiming to enhance the nutritional quality of crops. Multi-omics combines genomics, transcriptomics, proteomics, metabolomics, and other omics technologies to provide a comprehensive understanding of biological systems at multiple levels. These technologies facilitate the identification of key genes, pathways, and metabolites that contribute to nutritional traits and stress resilience in crops. Artificial Intelligence (AI) further amplifies this potential by analyzing complex omics data, predicting outcomes, and guiding precise genetic modifications. By utilizing AI, researchers can expedite the breeding process, optimize metabolic pathways, and tailor crops to meet specific nutritional goals. This integrative approach promises to revolutionize crop improvement strategies, addressing global challenges related to food security, malnutrition, and agricultural sustainability. The convergence of multi-omics and AI not only accelerates the development of nutrient-rich crops but also enhances their adaptability to environmental stresses, ensuring a more resilient and nutritious food supply.

Despite significant advancements in agricultural sciences, enhancing the nutritional quality of crops while maintaining their resilience to environmental stress remains a formidable challenge. Traditional breeding methods are often time-consuming and limited in scope, failing to address the complex genetic and metabolic networks underlying desirable traits. To overcome these limitations, we propose integrating multi-omics and AI-driven approaches. Multi-omics technologies provide a holistic view of the biological processes that determine nutritional quality and stress responses. AI algorithms can analyze vast and complex datasets, identifying key genetic targets and predicting the outcomes of genetic modifications with high precision. Recent advances include the development of AI models capable of integrating multi-omics data to optimize crop traits and the successful application of CRISPR/Cas9 for precise genome editing. By utilizing these cutting-edge tools, we can accelerate the breeding of crops with superior nutritional profiles and enhanced stress resilience, ultimately contributing to global food security and sustainable agriculture.

This research topic explores the integration of multi-omics and AI-driven approaches to enhance the nutritional quality and stress resilience of crops, aiming to develop innovative, sustainable solutions for global food security.

We welcome submissions of Original Research, Systematic Review, Mini Review, and Opinions, that focus on but not limited to the following topics:

1. Multi-omics integration for nutritional trait discovery.

2. AI in predictive modeling and data analysis for crop improvement.

3. Genome editing technologies (e.g., CRISPR) for nutrient enhancement.

4. Stress resilience mechanisms identified through omics.

5. Case studies on successful crop enhancement projects.

6. Ethical and regulatory considerations in AI-driven genetic manipulation.

7. Computational tools and pipelines for multi-omics data integration.

8. Impact of environmental factors on crop nutrition and resilience.

9. Metabolomics in nutrient bioavailability and crop quality.

10. Translational research from lab to field applications.

11. Multi-environment trials for nutrition improvement.

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Integrative Multi-omics and Artificial Intelligence (AI)-driven Approaches for Superior Nutritional Quality and Stress Resilience in Crops, Volume II