Over the past two decades, advancements in technology have significantly influenced neuropsychological rehabilitation for individuals with neurological disorders. Innovative tools such as virtual reality, mobile health applications, brain–computer interfaces, and non-invasive brain stimulation have demonstrated promising results in enhancing cognitive and behavioral recovery in conditions including stroke, traumatic brain injury, multiple sclerosis, and neurodegenerative diseases. These technologies increase the adaptability and ecological validity of interventions by creating immersive, real-life scenarios that facilitate the transfer of therapeutic gains to everyday functioning. Furthermore, they support remote and home-based rehabilitation, reducing barriers to access for neurologically affected populations. Despite their potential, integrating such tools into clinical practice remains challenging, particularly in terms of empirical validation, ethical considerations, and long-term feasibility. This Research Topic aims to present current evidence, highlight emerging approaches, and discuss the broader implications of technology-assisted interventions in neuropsychological rehabilitation and beyond.

The goal of this collection is to critically explore how technological innovation can advance neuropsychological rehabilitation, improving ecological validity, accessibility, and treatment outcomes for individuals with neurological disorders. Although interest in digital tools is increasing, their clinical application remains variable, with differences across settings and patient groups. This Research Topic will focus on evidence-based applications of virtual reality, mobile cognitive training, tele-rehabilitation, brain–computer interfaces, and non-invasive brain stimulation in the management of cognitive, emotional, and behavioral deficits. Special consideration will be given to studies that address intervention efficacy, feasibility, patient engagement, and transfer to daily life. We further seek to deepen understanding of underlying mechanisms, and examine methodological, ethical, and translational challenges of real-world implementation.

In addition to tertiary prevention and rehabilitation, we also welcome contributions that explore the role of these technologies in primary prevention and health promotion, such as cognitive enrichment, lifestyle modification, and resilience-building interventions aimed at reducing risk or delaying onset of neurological disorders. Empirical studies, theoretical contributions, protocol developments, and interdisciplinary research are all welcome.

We invite original research, randomized controlled trials, systematic reviews, theoretical contributions, and clinical case studies investigating technology-based interventions targeting cognitive, emotional, or behavioral outcomes across the lifespan. Relevant topics include:

• Ecological validity and real-world generalization
• Home-based and remotely delivered interventions
• Personalization, usability, and patient engagement
• Neural mechanisms and biomarkers of treatment response
• Methodological, ethical, and implementation challenges
• Multidisciplinary and translational approaches
• Technology-based strategies for primary prevention and health promotion

Studies involving patients with stroke, traumatic brain injury, neurodegenerative diseases, multiple sclerosis, or other neurological conditions are encouraged. All submissions should articulate clear clinical implications and promote evidence-based models for neuropsychological rehabilitation and health promotion.

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The Use of New Technologies in the Neuropsychological Rehabilitation of Patients with Neurological Disorders

Topic Coordinator