The field of inflammation-driven immune regulation is pivotal in decoding the pathogenesis of a wide spectrum of diseases, ranging from cancers to chronic and degenerative disorders. Dysregulation in inflammatory and immune processes not only underpins disease initiation and progression but also contributes significantly to the rising global burden of these conditions, especially amid aging populations and shifting environmental and lifestyle patterns. While fundamental research has advanced our understanding of key signaling pathways and immune cell dynamics, ongoing challenges include disease heterogeneity, limitations in diagnostic specificity, and gaps in preventative strategies. Recent studies integrating molecular biology, multi-omics, artificial intelligence, and epidemiological analyses are beginning to resolve some of these complexities, yet much remains to be understood about the mechanisms, early detection, and global impact of inflammation-driven diseases.

This Research Topic aims to consolidate cutting-edge discoveries in the mechanisms underpinning inflammation-related diseases and tumors, alongside breakthroughs in diagnostic and translational technologies. A key objective is to promote interdisciplinary research bridging basic science, clinical practice, data science, and global health perspectives. By fostering dialogue between immunologists, clinicians, computational biologists, and public health professionals, this Research Topic seeks to accelerate the development of early detection tools, precision interventions, and comprehensive prevention strategies tailored to diverse populations and settings.

In pursuit of a holistic understanding, the scope of this Research Topic encompasses both mechanistic insights and translational innovation in inflammation-driven immune regulation, with an emphasis on global trends and collaborative research. We encourage submissions addressing, but not limited to, the following themes:

• Mechanistic roles of inflammatory signaling pathways and immune cell regulation in disease initiation and progression
• Interactions between the immune microenvironment, tumors, and other inflammation-related diseases
• Applications of genomics, transcriptomics, proteomics, metabolomics, and other omics approaches in inflammation and immunity research
• Novel bioinformatics and systems biology methods for elucidating immune regulation mechanisms
• Innovative diagnostic strategies, including imaging technologies, artificial intelligence, and molecular biomarkers for early detection and precision management
• Emerging therapeutic targets and intervention strategies related to inflammation and immune modulation
• Applications of global burden of disease analysis, bibliometrics, and big data approaches in inflammation and immunity research
• Multidisciplinary and multicenter collaborations in advancing research and prevention of inflammation-related diseases

We welcome the submission of original research articles, reviews, perspectives, and case reports as part of this Research Topic.

Are you interested in contributing a manuscript to this Research Topic?

Inflammation-Driven Immune Regulation: Emerging Mechanisms, Diagnostic Innovations, and Global Perspectives