Aging fundamentally transforms the human genome through accumulative epigenetic modifications—including DNA methylation, histone modifications, and changes in non-coding RNA expression. These age-dependent epigenetic changes profoundly affect the immune system, shaping immune cell function, diversity, and responsiveness. The complex interplay between aging, epigenetics, and immunity is increasingly recognized as a driving force in cancer progression, therapeutic response, and clinical outcomes.

This Research Topic seeks to bring together diverse contributions to better understand how age-related epigenetic changes modulate immune responses during cancer development and progression. We welcome all article types, including but not limited to: original research articles, reviews, mini-reviews, perspectives, systematic reviews, case reports, brief research reports, hypothesis & theory articles, methods, data reports, and opinion pieces.

Key questions and themes of interest include:

- How do age-dependent epigenetic modifications impact immune surveillance and the tumor microenvironment?

- What molecular mechanisms connect epigenetic aging with immune dysfunction in cancer?

- Can targeting epigenetic pathways rejuvenate aging immune responses and improve cancer immunotherapy outcomes?

- What roles do non-coding RNAs and chromatin remodeling play in the aging of immune cells in oncological settings?

- Are there emerging biomarkers or novel therapeutic targets at the intersection of aging, epigenetics, and cancer immunity?

Multidisciplinary contributions are especially encouraged, including studies leveraging technological advances such as multi-omics, single-cell approaches, computational modeling, and translational animal/human models. By fostering dialogue across disciplines and article types, this collection aims to inspire innovative insights that will advance precision medicine for aging and cancer.

Are you interested in contributing a manuscript to this Research Topic?

Age-Dependent Epigenetic Modifications Shaping Immune Responses in Cancer Progression