Environmental health research is increasingly recognizing the profound influence of complex, lifelong exposures—such as chemical pollutants, dietary components, and lifestyle factors—on the integrity of the endocrine system. While genetics play a role in endocrine and metabolic disease risk, growing evidence demonstrates that the exposome—defined as the totality of external and internal exposures—can drive endocrine disruption through oxidative stress, metabolic dysregulation, and gene-environment interactions. High-resolution exposomics and metabolomics platforms now allow for comprehensive, simultaneous assessment of environmental exposures and metabolic profiles, providing unprecedented opportunities to map mechanisms underpinning endocrine and reproductive disorders. However, gaps remain in connecting exposure-driven metabolic perturbations to clinical endocrine outcomes, especially regarding the integration of epigenomics and other omics with exposomics and metabolomics data.

This Research Topic aims to bridge the gap between environmental exposures and endocrine health by advancing integrative exposomic and metabolomic approaches. We seek to deepen understanding of how technological innovations in measurement and data analysis can clarify the causal links between exposure mixtures and endocrine disruption, identify pivotal metabolic pathways, and establish new biomarkers with translational value. By focusing on the interplay between the exposome, metabolome, and endocrine regulation, this Topic encourages research that moves beyond association, elucidating mechanisms and pathways amenable to targeted intervention and prevention strategies.

To gather further insights into the interface between environmental exposures and endocrine system integrity, we welcome articles addressing, but not limited to, the following themes:
o Technological advances in exposomics and metabolomics for endocrine research
o Role of the exposome and metabolome in oxidative stress and endocrine disruption
o Applications of exposomics and metabolomics in endocrine and reproductive diseases
o Modulation of endocrine metabolism by diet and lifestyle exposures
o Discovery of metabolic biomarkers and therapeutic approaches for exposure-induced endocrine disorders
o Exposome-induced perturbations in endocrine metabolic pathways
o Influence of exposure-driven metabolites on epigenetic modulation of endocrine gene regulation
o Omics integration: combining exposomics and metabolomics with epigenomics, transcriptomics, or proteomics for endocrine health research

We welcome submissions including, but not limited to, Original Research, Review, and Mini Review articles. Submissions highlighting innovative methodologies, mechanistic insights, and translational perspectives in the exposome–endocrine axis are especially encouraged.

Are you interested in contributing a manuscript to this Research Topic?

Exposomics and Metabolomics: Bridging Environmental Exposures with Endocrine Health