This Research Topic is the second volume of the Research Topic "Photobiomodulation Therapy for Brain Disorders". Please see the first volume here .

Photobiomodulation (PBM), previously termed low-level laser (light) therapy, applies relatively low levels of visible or near-infrared light to generate beneficial biological effects in living cells and tissues. In previous studies, PBM has been used to stimulate healing, relieve pain and inflammation, and preserve tissue function. Recently, PBM has attracted increasing attention due to its massive potential in neuroprotection via anti-inflammatory, anti-oxidative, and mitochondrial protective properties. Although PBM has gained substantial attention in neuroscience and exhibited significant potential in treating and preventing brain disorders, many questions regarding PBM remain unresolved, including the effects, the optimal treatment regimes, and the precise mechanism(s) of PBM for preventing and treating various brain diseases.

Understanding the effects of PBM with the different treatment regimens on various brain disorders and deciphering a more in-depth understanding of the underlying molecular mechanism(s) will be of high research and clinical value in the clinical management of various brain diseases, including neurodegenerative diseases, brain injury, and psychiatric disorders. This research topic aims to collect studies evaluating the effects of PBM therapy with multiple parameters on brain diseases, including but not limited to Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, ischemia stroke, traumatic brain injury, neonatal hypoxia-ischemia, anxiety, depression, and post-traumatic stress disorder. Original papers uncovering the novel mechanisms underlying PBM‘s neuroprotection and reviews discussing the recent advances and challenges in this field are expected. We also welcome case reports involving PBM in brain disease treatment.

Potential areas of interest may include, but are not limited to:

1) The preparative or conditioning regimen of PBM therapy on various brain diseases, including neurodegenerative diseases, brain injury, and psychiatric disorders;

2) The mechanism underlying the neuroprotective effects of transcranial and remote PBM therapy in brain diseases;

3) The similarities and differences between transcranial and remote PBM in preventing and treating brain diseases;

4) The similarities and differences between the pulsed and continuous wave PBM in the neuroprotective effects and the underlying mechanisms;

5) Strategies to improve the therapeutic potential of PBM therapy.

Are you interested in contributing a manuscript to this Research Topic?

Photobiomodulation Therapy for Brain Disorders Volume II