This section showcases rigorous, in-depth research at the intersection of computational biology and RNA science, with an emphasis on methodological innovation and practical utility. We welcome contributions that develop, evaluate, or apply computational methods, software tools, and analytical frameworks across the full spectrum of RNA bioinformatics, including but not limited to:

- Databases, knowledge graphs, and web portals for RNA data discovery, integration, and visualization

- High-throughput RNA sequencing (bulk and targeted) and advanced experimental-computational workflows

- Non-coding RNAs (miRNA, lncRNA, circRNA, piRNA, and beyond): annotation, function prediction, and regulatory modeling

- RNA networks and systems-level approaches to RNA regulation, signaling, and pathway dynamics

- RNA–RNA interactions: prediction, mapping, structural modeling, and validation strategies

- RNA sequence mapping and quantification: alignment, transcriptome assembly, isoform resolution, and error modeling

Single-cell and spatial transcriptomics: algorithms for denoising, integration, lineage inference, and cell-state dynamics

We particularly encourage submissions that:
- Introduce novel algorithms or statistically principled models with clear performance benchmarking

- Deliver robust, user-friendly software, reproducible pipelines, and FAIR-compliant resources

- Integrate multi-omics data or structural information to deepen mechanistic insight

- Address scalability, interpretability, uncertainty quantification, and reproducibility in RNA analyses

- Translate methods to impactful applications in health, biotechnology, and environmental sciences

Positioned at the forefront of RNA research, this multidisciplinary section serves as a hub for disseminating cutting-edge discoveries to researchers, industry stakeholders, policymakers, and the public. By advancing the methods and tools that power modern RNA biology, we aim to accelerate understanding of RNA function, regulation, and therapeutic potential in a rapidly evolving field.

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Methods, Tools and Algorithms in RNA Bioinformatics