The integration of nanotechnology with bioinspired materials is rapidly transforming the landscape of advanced healthcare solutions. Despite the remarkable progress in creating materials that emulate natural structures and functions, current clinical challenges, such as ensuring biocompatibility, precise targeting, and adaptive therapeutic responses, are not fully resolved by conventional approaches. Recent groundbreaking research demonstrates that nanostructured bioinspired materials can not only interact dynamically with biological tissues but also enable unprecedented functionalities, from programmable drug release to real-time biosensing and tissue regeneration. Nevertheless, the safe and effective translation of these innovations into clinical use is still hindered by obstacles including manufacturing scalability, regulatory validation, and systematic long-term evaluation. While interdisciplinary efforts are beginning to bridge these gaps, there remains a pressing need for unified strategies and new insights to move these advanced materials from the laboratory into real-world medical practice.

This Research Topic aims to advance understanding and foster innovation in nanotechnology-driven bioinspired materials that address urgent healthcare needs. The objective is to highlight pioneering research, critical challenges, and emerging solutions that enhance clinical outcomes through improved material design, delivery strategies, and diagnostic capabilities. By cultivating interdisciplinary collaboration, this Research Topic strives to uncover the mechanisms that underpin improved therapeutic efficacy, patient-specific performance, and long-term safety, setting the stage for future breakthroughs in medical technology.

This Research Topic focuses on the development, characterization, and application of nanotechnology-enhanced bioinspired materials for advanced healthcare, outlining current achievements and unresolved issues. Contributions should emphasize translational potential and cross-disciplinary advancements. We welcome articles addressing, but not limited to, the following themes:

- Novel design and fabrication strategies for bioinspired nanomaterials

- Interactions and integration with biological tissues and cells

- Smart systems for targeted drug delivery and controlled therapeutic release

- Materials for biosensing, diagnostics, and regenerative medicine

- Biocompatibility assessment and safety validation

- Regulatory challenges and clinical translation pathways

- Patient-specific customization and long-term monitoring of materials

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Nanotechnology-Enhanced Bioinspired Materials for Advanced Healthcare Applications