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Advances in Steroid-Responsive Encephalopathy

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Steroid-responsive encephalopathy is a general term used to describe diseases characterized by diffuse brain injury and responsiveness to corticosteroids or immunosuppressive therapies. These diseases include Hashimoto's encephalopathy, limbic encephalitis, systemic lupus erythematosus encephalopathy, ...

Steroid-responsive encephalopathy is a general term used to describe diseases characterized by diffuse brain injury and responsiveness to corticosteroids or immunosuppressive therapies. These diseases include Hashimoto's encephalopathy, limbic encephalitis, systemic lupus erythematosus encephalopathy, ANCA-related vasculitis encephalopathy, viral encephalitis and primary central nervous system lymphoma.

The disease is very common in clinical practice but is usually misdiagnosed. The abovementioned disorders are sensitive to corticosteroids; however, corticosteroids are not effective in most patients with the disorders. Additionally, the treatment of affected patients may be complicated by the various side effects of corticosteroids.

Exploring steroid-responsive encephalopathy is important, as studying the disease will enable us to improve our understanding of its characteristics, diagnosis, prognosis, and underlying pathophysiological and pathogenetic mechanisms.

Authors engaged in studying the topic of steroid-responsive encephalopathy are encouraged to perform studies whose focus is predominantly clinical, including studies focusing on the discovery and validation of diagnostic, prognostic and predictive markers for the disease. The field welcomes investigative studies on human tissues, in vitro and in vivo experimental studies, and investigations based on animal models, including transgenic systems, that clearly mimic the human disease. In addition to contributing original research papers, solicited or otherwise, investigators should also seek to provide a variety of other publications, including editorials, review articles, commentaries and perspectives and other works. All papers contributed to the field will be subjected to strict peer review.


Keywords: Steroid-responsive encephalopathy, Mechanism, Diagnosis, Treatment, Prognosis


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