Sustainable food systems are increasingly advancing through the use of soft-matter architectures—such as liposomes, emulsions, oleogels, hydrogels, and colloids—that protect, stabilize, and deliver sensitive bioactives like omega fatty acids. Designing nanostructured, food-grade materials grants precise control over interfacial properties, texture, release kinetics, and oxidative stability. However, polyunsaturated lipids remain particularly prone to degradation during processing, storage, and gastrointestinal digestion, resulting in reduced bioaccessibility and nutritional efficacy. Simultaneously, recent studies highlight the important role of omega fatty acid delivery in downstream biological processes, including their conversion into specialized pro-resolving mediators (SPMs) and the regulation of immunometabolic pathways relevant to systemic and neuroinflammatory health. Bridging innovative soft-matter designs with robust translational bioactivity metrics can drive progress toward sustainable, functional formulations that maximize stability, bioavailability, and health impacts of omega fatty acids.

This Research Topic aims to advance the development of sustainable, nanostructured soft-matter systems that improve the stability, targeted delivery, and bioavailability of omega fatty acids while also linking these advances to clear measures of biological efficacy. We encourage studies that design edible matrices—including proteins, polysaccharides, Pickering interfaces, and gel networks—to limit oxidation and tune release profiles, as well as work that rigorously quantifies digestion, absorption, and uptake using best-practice models. Contributions connecting delivery formats to functional biological outcomes—such as SPM generation (resolvins, protectins, maresins), modulation of immunometabolic pathways (IRG1/itaconate axis, Th17/Treg balance, microglial metabolism), and shifts in relevant biomarkers—are especially welcome. Integrated approaches using metabolomics, metabolipidomics, high-sensitivity biomarker assays, and artificial intelligence or machine learning to map formulation parameters to bioactivity are strongly encouraged. By directly linking soft-matter food physics with translational outcomes, this Topic seeks to highlight sustainable solutions that deliver both improved stability and meaningful health benefits.

We invite original research articles, reviews, perspectives, short communications, and methods papers focused on:

- The design, self-assembly, rheology, oxidative stability, and controlled release of omega fatty acids in soft-matter food systems;
- Nanoencapsulation and nanoengineering of food-grade emulsions, oleogels, hydrogels, liposomes, and Pickering systems;
- In vitro digestion and bioaccessibility studies using standardized models (e.g., INFOGEST), alongside relevant in vivo or in vitro efficacy readouts;
- Research on the bioconversion of omega fatty acids into SPMs, as well as the impact of advanced delivery systems on immunometabolic and neuroinflammatory pathways and related biomarkers;
- Integration of AI/ML models that connect formulation descriptors with data from multi-omic and functional bioactivity analyses.

Are you interested in contributing a manuscript to this Research Topic?

Sustainable Nanostructured Soft-Matter Food Systems for Stable and Bioavailable Omega Fatty Acids