Regenerative medicine has emerged as one of the most dynamic fields of modern biomedical research, and stem cells continue to stand at the center of this progress. Their unique capacity for self renewal, lineage commitment, and tissue reconstruction has opened transformative avenues for treating diseases that were previously considered irreversible. This Research Topic focuses on recent innovations that leverage stem cell biology to develop advanced therapeutic strategies, understand disease mechanisms, and engineer complex tissue systems.

The field has rapidly expanded beyond traditional stem cell transplantation, integrating cutting edge technologies such as induced pluripotent stem cells, single cell omics, bioengineering platforms, and organoid systems. These innovations offer unprecedented insight into human development, cell fate decisions, and tissue level repair. Stem cell derived models allow researchers to recreate cellular environments that closely resemble human physiology, enabling the study of complex disorders with greater accuracy. In addition, advances in gene editing and synthetic biology are enhancing the precision and safety of stem cell based therapies, ensuring that personalized regenerative solutions can be designed with minimal risk.

Another major advancement lies in the integration of biomaterials with stem cells to promote targeted regeneration. Smart scaffolds created using hydrogels, extracellular matrix mimetics, and 3D bioprinting technologies provide biochemical and mechanical cues that guide cell behavior. These approaches support tissue patterning, vascular growth, and immune modulation, all of which are essential for translating stem cell therapies into clinically viable treatments. Moreover, the development of organ on chip platforms allows controlled microenvironmental manipulation, helping researchers test new drugs, study mechanical forces, and model chronic pathologies in real time.

This Research Topic aims to bring together new experimental approaches, mechanistic discoveries, and translational advancements that highlight how stem cell technology is reshaping regenerative medicine. Contributions focusing on interdisciplinary strategies, novel therapeutic pipelines, and disease modeling platforms are especially encouraged as the field moves toward personalized and scalable medical solutions.

We welcome original research articles, systematic reviews, meta-analyses, mini reviews, and clinical case studies within the scope of this Research Topic. Submissions may include work on the following areas

• Stem cell based strategies for tissue regeneration and repair

• Organoid and organ on chip models for disease investigation

• Advances in gene editing for enhancing regenerative outcomes

• Biomaterial innovations and 3D bioprinting for guided tissue formation

• Stem cell applications in neurodegeneration and cardiovascular medicine

• Immune regulation and safety assessment in stem cell therapy

• Translational challenges and emerging clinical applications

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Innovations in Regenerative Medicine: Harnessing the Power of Cells