Research Topic

Dosimetry Study in Photodynamic Therapy for Diagnosis, Precision Treatment and Treatment Evaluation

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Photodynamic therapy (PDT) is a light-based photochemistry process that involves a drug (photosensitizer) and light source with the right emission wavelength to generate highly reactive species to kill local affected cells. PDT has proven to be a promising modality in many medical applications including ...

Photodynamic therapy (PDT) is a light-based photochemistry process that involves a drug (photosensitizer) and light source with the right emission wavelength to generate highly reactive species to kill local affected cells. PDT has proven to be a promising modality in many medical applications including cutaneous condition, infectious diseases, and various cancers at different stages. PDT can be a beneficial adaption in the clinic due to the advantages of minimal side effect, relatively easy and safe operation and low resource demand in hardware. At the same time, the dosimetry of PDT can be quite complicated since many factors are involved in the treatment planning, monitoring and efficacy evaluation.

Besides helping to understand the photobiology process from the research perspective better, the study of PDT dosimetry is crucial to ensure the reliability and reproducibility of this modality and to further expand its impact on clinical applications. Uncontrollable overdose or under-dose will compromise the efficacy and promotion of this modality in the clinical treatment.

The dosimetry research of PDT is a cross-disciplinary subject including physics, chemistry, photobiology and others. It can be merely measuring the fluorescence intensity or require the comprehensive measurement of many relevant parameters in the surgical procedure of clinical studies. In practical, most clinical PDT procedures around the world only involve the calculation of drug dose and delivered light dose at lesion surface.

Understanding of the different stage of dosimetry, from fundamental cellular level process to the tissue response, is not only scientifically interesting but also directly relevant to the planning and evaluation of clinical approach. It will improve the accuracy of treatment response of patients and may even facilitate the precision personalized treatment in the future. To translate the research results of precision dosimetry into a clinically acceptable format, research on new technologies and suitable surrogate dosimeter are needed.

In this Research Topic, we welcome submissions on PDT dosimetry related research in areas including numerical simulation, in vitro and in vivo research, technology development and various stages of clinical study.


Keywords: Photodynamic therapy, dosimetry, precision


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