Research Topic

Tandem Extracranial-Intracranial Lesions in Acute Ischemic Stroke

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During the last years, endovascular treatment has evolved as the standard of care for acute ischemic stroke with large vessel occlusions. Currently, still numerous unanswered questions remain, e.g. regarding the organization of stroke networks, the value of IV tpA pretreatment. One important topic in ...

During the last years, endovascular treatment has evolved as the standard of care for acute ischemic stroke with large vessel occlusions. Currently, still numerous unanswered questions remain, e.g. regarding the organization of stroke networks, the value of IV tpA pretreatment. One important topic in contemporary acute stroke care is the treatment of so called tandem lesions (i.e. extracranial carotid in combination with an intracranial occlusion). Several large cohort series have been published and some subgroup analysis of randomized trials have been performed. Most of them suggested to treat tandem lesions endovasculary. However, there are several options to do so with regards to timing, endovascular technique, periprocedural medication and also considering the underlying pathology (atherosclerosis versus dissection). How all these factors contribute to the outcome of patients is poorly understood. Moreover, there is uncertainty of how patients with tandem lesions differ in their clinical outcome or their rehabilitation potential. Besides these clinical factors, only very little is known on the pathogenesis of this disease e.g. why do some patients end up with a chronic carotid occlusion while other suffer from an acute stroke with a tandem lesion?
To elucidate all these topics we would like to collect current research results on tandem lesions from all specialties dealing with this interesting subtype of acute ischemic stroke.


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