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Stroke has been among the most rapidly evolving field of medicine in the last three decades. From an area filled with nihilism and unproven dogmas, an incredible research momentum has led to major breakthroughs in understanding for instance i) the mechanisms leading to ischemic and hemorrhagic stroke, including vascular, hematological and genetic factors, and those underlying the outcome of acutely ischemic tissue, namely infarction or survival, and the benefits of early reperfusion ; ii) the events that take place in peri-lesional tissue, including inflammation, selective neuronal death and plasticity; iii) the processes underlying brain reorganization and functional recovery; and iv) the contribution of incipient vascular brain damage in the cognitive deterioration including dementia of the elderly. These advances have led to clinical revolutions for instance in the secondary prevention of stroke, acute stroke therapy, management of transient ischemic attacks and subarachnoid hemorrhage, and neurorehabilitative interventions, that have had major impact on both mortality and functional outcome.
However, the incidence of stroke remains extremely high due to aging populations worldwide, the fraction of patients who benefit from these advances remains limited and overall stroke outcome remains unsatisfactory. Hemorrhagic stroke remains a major challenge in terms of both lack of evidence-based acute therapy and risk related to antithrombotic therapies in the elderly. Likewise, the mechanisms underlying cerebral small vessel disease (cSVD), including hypertension-related cSVD and cerebral amyloid angiopathy, remain largely unknown, yet their incidence and impact increase dramatically with aging of the populations. There is therefore an urgent need to further improve stroke therapy and outcome through basic, translational and clinical research. Additional challenges that face stroke scientists in the next decades include the major heterogeneity in clinical presentations/phenotypes, stroke subtypes and etiologies, the complex interactions between the brain, the blood vessels and the remainder of the body, and the marked differences in access to and quality of stroke management depending on country and actual place of living and economic status of patients.
The Stroke section aims to quickly publish important experimental, translational and clinical studies - both original and review articles - that contribute to the knowledge of stroke, its mechanisms, consequences, manifestations, diagnosis, prevention and management.
Indexed in: PubMed, PubMed Central, Scopus, Google Scholar, DOAJ, CrossRef, EMBASE, Science Citation Index Expanded, CLOCKSS
PMCID: all published articles receive a PMCID
Stroke welcomes submissions of the following article types: Brief Research Report, Case Report, Clinical Study Protocol, Clinical Trial, Correction, Editorial, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review and Systematic Review.
All manuscripts must be submitted directly to the section Stroke, where they are peer-reviewed by the Associate and Review Editors of the specialty section.
Articles published in the section Stroke will benefit from the Frontiers impact and tiering system after online publication. Authors of published original research with the highest impact, as judged democratically by the readers, will be invited by the Chief Editor to write a Frontiers Focused Review - a tier-climbing article. This is referred to as "democratic tiering". The author selection is based on article impact analytics of original research published in all Frontiers specialty journals and sections. Focused Reviews are centered on the original discovery, place it into a broader context, and aim to address the wider community across all of Neurology.