REVIEW article
Front. Neurol.
Sec. Stroke
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1630671
This article is part of the Research TopicReviews in Preventative Health for Stroke and Education to Stroke PreventionView all 10 articles
Association between atopic dermatitis and risk of stroke: A systematic review and meta-analysis
Provisionally accepted
- 1Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, China
- 2Three Gorges University, Gezhouba Central Hospital of Sinopharm, Yichang, China
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Background/Objectives: Recent studies have sought to determine the correlation between atopic dermatitis (AD) and the occurrence of stroke; however, these investigations have not reached a consensus. Consequently, our team conducted this meta-analysis and systematic review to further explore the potential relationship between these two conditions.Methods: A comprehensive literature search was conducted across PubMed, Embase, and Web of Science from their inception until January 2025 to identify observational studies examining the association between atopic dermatitis and stroke risk. Random-effects meta-analyses were performed using the generic inverse variance method, and hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated. Additionally, sensitivity analyses and subgroup analyses were conducted to assess the stability of the results and explore potential sources of heterogeneity.This meta-analysis included 12 observational studies, comprising 8 cohort studies, 2 case-control studies, and 3 cross-sectional studies, with a total of 14,517,146 participants. The analysis revealed a significant correlation between AD and the risk of stroke (n=17, OR=1.27,95%CI=1.14-1.43). Subgroup analyses indicated a particularly strong association among males (n=3, OR=1.31, 95% CI=1.07-1.60) and in the context of ischemic stroke types (n=5, OR=1.14 95%CI=1.00-1.30). Furthermore, sensitivity analyses demonstrated that the results were stable and reliable.AD is independently associated with an increased risk of stroke, especially in men, and there is a notable association with ischemic stroke. Moreover, the risk appears to be positively correlated with the severity of AD.
Keywords: atopic dermatitis, Stroke, Meta-analysis, risk, systematic review 1. Introduction
Received: 18 May 2025; Accepted: 27 Jun 2025.
Copyright: © 2025 Pan, Han, Zeng, Wang, Xiong, Wu and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qing ping Han, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, China
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