About this Research Topic
NK cell activation is a complex process that is modulated by various types of receptors that exhibit either inhibitory or activating signaling functions. Some of these receptors recognize epitopes on MHC class I molecules or MHC class I like structures. These are known as the KIR and CD94/NKG2, and LY49 receptors. While in primates the KIR and CD94/NKG2 receptors dominate, rodents employ a completely different system of polymorphic (LY49) receptors that has arisen due to convergent evolution.
In this Research Topic, we aim to bring together the leaders in the field to provide an extensive overview of the current state of the art, highlighting different aspects of NK cell receptor evolution and function in different vertebrate species, seen from the perspective of comparative genetics. We welcome the submission of Original Research; Hypothesis and Theory; Mini-Review, Review, Systematic Review and Perspective articles in this Research Topic.
Keywords: NK cell, NK cell receptor, MHC Class I, KIR, CD94, NKG2, LY49
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