Purinergic Signaling in Health and Disease

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Editorial

04 February 2020

Editorial: Purinergic Signaling in Health and Disease

Eric Boué-Grabot

,

David Blum

and

Stefania Ceruti

2,278 views

4 citations

Editors

3

Eric Boué-Grabot

UMR5293 Institut des Maladies Neurodégénératives (IMN)

David Blum

INSERM U1172 Centre de Recherche Jean Pierre Aubert

Stefania Ceruti

Department of Pharmacological and Biomolecular Sciences, Faculty of Pharmacy, University of Milan

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Adenosine 5’-triphosphate (ATP) is one of the most abundant molecule in living cells serving as universal energy “currency.” After slow acceptance of the concept of the release and extracellular action of ATP, purinergic signaling is recognized as a widespread mechanism for cell-to-cell communication in living organisms. Additionally, the contribution of pyrimidine nucleotides (such as UTP and UDP) and sugar-nucleotides (i.e., UDP-glucose and UDP-galactose) have been more recently discovered. Purinergic signaling plays major physiological roles in mammalian central nervous system (CNS) such as neurotransmission, neuromodulation, communication in glial network and between neurons and glia. Extracellular ATP and its metabolic breakdown is a source of other nucleotides and adenosine providing the versatile basis for complex purinergic signaling through the activation of several families of purinergic receptors. G-protein coupled P1 receptors for adenosine, ionotropic P2X receptors for ATP and G-protein coupled P2Y receptors for ATP and other nucleotides are abundant and widely distributed in central neurons at pre-and post-synapse and in glial cells. Alterations of purinergic signals are associated with major CNS disorders including chronic pain, brain trauma ischemia, epilepsy, neurodegenerative diseases such as Alzheimer disease or Amyotrophic lateral sclerosis associated with neuro-inflammation as well as neuropsychiatric diseases, including depression, anxiety and schizophrenia.

The goal of this Research Topic is to assemble high quality review articles and original research articles, covering the fields of adenosine receptors, P2X receptors, P2Y receptors and ectonucleotidases to provide an up-to-date and global insight of the diversity of the purinergic signals in the central nervous system in physiological and pathological conditions. This will also serve as a comprehensive overview of the interplay between several purinergic receptors subtypes and/or ectonucleotidases at molecular and cellular levels in a specific physiological or clinical context.

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Editors

Eric Boué-Grabot

UMR5293 Institut des Maladies Neurodégénératives (IMN)

David Blum

INSERM U1172 Centre de Recherche Jean Pierre Aubert

Stefania Ceruti

Department of Pharmacological and Biomolecular Sciences, Faculty of Pharmacy, University of Milan

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109,181 Article views

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Published In

Frontiers in Cellular Neuroscience

Non-Neuronal Cells, Cellular Neurophysiology, Cellular Neuropathology

Frontiers in Molecular Neuroscience

Molecular Neuroscience Archive, Brain Disease Mechanisms, Molecular Signalling and Pathways, Pain Mechanisms and Modulators, Neuroplasticity and Development

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