Research Topic

Multitasking Biomolecules in Human Pathologies: Known Players on Their Unexpected Journeys

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About this Research Topic

Over the last few years, a number of studies have brought forward new and exciting discoveries in biomolecule research and have changed the old paradigm "one molecule, one function, one trait". Today, we know that one biomolecule may operate in different locations, utilize different substrates and interactions thus performing multiple, also unrelated functions. Interestingly, these properties are not only reserved for proteins, also DNA and RNA molecules as well as diverse classes of metabolites possess the ability to multitask. The discovery of multifunctionality of biomolecules as well as their “moonlighting business” led to the identification of new interaction networks and provided novel insights into the pathogenesis of many disorders. In addition, it opened new horizons for the diagnosis and treatment of several diseases and for drug repurposing and development. In this Research Topic, we would like to present new faces of "old" molecules and discuss their significance for biomedical research.


Keywords: Moonlighting factors, Molecular pathomechanism, Multitasking proteins, Network hubs, Drug discovery


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Over the last few years, a number of studies have brought forward new and exciting discoveries in biomolecule research and have changed the old paradigm "one molecule, one function, one trait". Today, we know that one biomolecule may operate in different locations, utilize different substrates and interactions thus performing multiple, also unrelated functions. Interestingly, these properties are not only reserved for proteins, also DNA and RNA molecules as well as diverse classes of metabolites possess the ability to multitask. The discovery of multifunctionality of biomolecules as well as their “moonlighting business” led to the identification of new interaction networks and provided novel insights into the pathogenesis of many disorders. In addition, it opened new horizons for the diagnosis and treatment of several diseases and for drug repurposing and development. In this Research Topic, we would like to present new faces of "old" molecules and discuss their significance for biomedical research.


Keywords: Moonlighting factors, Molecular pathomechanism, Multitasking proteins, Network hubs, Drug discovery


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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