Research Topic

Pre-clinical Models of PTSD

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Posttraumatic stress disorder (PTSD) affects up to 7-8% of individuals in the United States causing moderate to severe impairment in over two thirds of patients. Yet, much remains unknown about pathophysiology and why some individuals recover from trauma while other develop pathological responses. The use of ...

Posttraumatic stress disorder (PTSD) affects up to 7-8% of individuals in the United States causing moderate to severe impairment in over two thirds of patients. Yet, much remains unknown about pathophysiology and why some individuals recover from trauma while other develop pathological responses. The use of animal models of PTSD has enabled exploration of mechanistic underpinnings of pathophysiological processes involved, and the variety of mediating/contributing factors including genetics, sex, age, early life experiences, substance use, sleep disturbance, etc. Currently, several preclinical models of PTSD are in use to explore subsets of traits altered in PTSD and potential interventions targeting resilience or recovery from trauma.

In this Research Topic, we welcome papers that use preclinical animal models to advance understanding of PTSD-related pathophysiology, including factors affecting vulnerability, resilience and recovery, PTSD symptoms development, PTSD comorbidities and treatment response. We encourage authors to submit original research manuscripts, but we will consider reviews or perspective pieces that offer novel perspective or conceptual development. Authors should highlight how their submission relates to the aforementioned goals of this special edition and the theme of preclinical models of PTSD.


Keywords: PTSD, pre-clinical, animal models, preclinical


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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