Pre-clinical Models of PTSD

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Editorial

15 October 2019

Editorial: Pre-clinical Models of PTSD

Shane A. Perrine

and

Israel Liberzon

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Israel Liberzon

Texas A and M University

Shane Alan Perrine

School of Medicine, Wayne State University

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Posttraumatic stress disorder (PTSD) affects up to 7-8% of individuals in the United States causing moderate to severe impairment in over two thirds of patients. Yet, much remains unknown about pathophysiology and why some individuals recover from trauma while other develop pathological responses. The use of animal models of PTSD has enabled exploration of mechanistic underpinnings of pathophysiological processes involved, and the variety of mediating/contributing factors including genetics, sex, age, early life experiences, substance use, sleep disturbance, etc. Currently, several preclinical models of PTSD are in use to explore subsets of traits altered in PTSD and potential interventions targeting resilience or recovery from trauma.

In this Research Topic, we welcome papers that use preclinical animal models to advance understanding of PTSD-related pathophysiology, including factors affecting vulnerability, resilience and recovery, PTSD symptoms development, PTSD comorbidities and treatment response. We encourage authors to submit original research manuscripts, but we will consider reviews or perspective pieces that offer novel perspective or conceptual development. Authors should highlight how their submission relates to the aforementioned goals of this special edition and the theme of preclinical models of PTSD.

Posttraumatic stress disorder (PTSD) affects up to 7-8% of individuals in the United States causing moderate to severe impairment in over two thirds of patients. Yet, much remains unknown about pathophysiology and why some individuals recover from trauma while other develop pathological responses. The use of animal models of PTSD has enabled exploration of mechanistic underpinnings of pathophysiological processes involved, and the variety of mediating/contributing factors including genetics, sex, age, early life experiences, substance use, sleep disturbance, etc. Currently, several preclinical models of PTSD are in use to explore subsets of traits altered in PTSD and potential interventions targeting resilience or recovery from trauma.

In this Research Topic, we welcome papers that use preclinical animal models to advance understanding of PTSD-related pathophysiology, including factors affecting vulnerability, resilience and recovery, PTSD symptoms development, PTSD comorbidities and treatment response. We encourage authors to submit original research manuscripts, but we will consider reviews or perspective pieces that offer novel perspective or conceptual development. Authors should highlight how their submission relates to the aforementioned goals of this special edition and the theme of preclinical models of PTSD.

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Editors

Israel Liberzon

Texas A and M University

Shane Alan Perrine

School of Medicine, Wayne State University

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Frontiers in Behavioral Neuroscience

Behavioral Neuroscience Archive, Emotion Regulation and Processing, Behavioral Endocrinology, Individual and Social Behaviors, Learning and Memory, Motivation and Reward, Pathological Conditions

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