About this Research Topic
Ubiquitin ligases refers to a family of proteins that are widely distributed in animals and plants and act as key regulators of cell metabolism and cell signaling. Recent reviews nicely describe our current understanding of the function of specific classes of ubiquitin ligases. However, a more holistic account of ubiquitin ligases in health and disease remain as an important pending assignment in the field.
This Research Topic addresses this gap in knowledge and aims to include contributions from leading scientists with a long-standing interest in ubiquitin ligases, ranging from the study of the function and structure of HECT-type, RNA-binding, SCF, E1, and E3 ubiquitin ligase; alternative Ubiquitin-modification Pathways; Cullin-RING ubiquitin ligase complex, to the discovery of inhibitors and activators of RING and U-box type E3 Ligases; and the role of ubiquitin ligases in autophagy and of ubiquitin-modifying enzymes in the regulation of the immune response.
Keywords: ubiquitin-modifying enzymes, ubiquitination, protein degradation, ligases, drug target
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