Research Topic

Neutrophil-Mediated Skin Disorders

About this Research Topic

Neutrophil-mediated skin diseases encompass a wide spectrum of diseases characterized by polymorphic cutaneous manifestations. They are histopathologically hallmarked by sterile neutrophilic infiltrates involving the skin and, more rarely, the internal organs. Neutrophil-mediated skin diseases share ...

Neutrophil-mediated skin diseases encompass a wide spectrum of diseases characterized by polymorphic cutaneous manifestations. They are histopathologically hallmarked by sterile neutrophilic infiltrates involving the skin and, more rarely, the internal organs. Neutrophil-mediated skin diseases share clinicopathological features with those of autoinflammatory diseases, which present in patients with recurrent episodes of aseptic inflammation in the affected organs in absence of allergy or frank autoimmunity. In classic autoinflammatory diseases, mutations in genes regulating innate immune responses leads to altered activation of the inflammasome. The inflammasome is a molecular platform responsible for triggering autoinflammatory processes via the uncontrolled release of interleukin (IL)-1β, as well as other proinflammatory cytokines and chemokines, leading to neutrophil recruitment into the affected organs.

Increasing evidence indicates that pro-inflammatory cytokines such as IL-1β, in synergy with IL-17 and tumour necrosis factor (TNF)-alpha, play a pivotal role in the pathophysiology of neutrophil-mediated skin diseases. Moreover, mutations in autoinflammatory genes, like Proline-Serine-Threonine Phosphatase Interacting Protein 1 (PSTPIP1), have been demonstrated in neutrophil-mediated skin diseases such as pyoderma gangrenosum and its syndromic presentation known as PASH (pyoderma gangrenosum, acne and suppurative hidradenitis), giving rise to a spectrum of polygenic autoinflammatory conditions.

The aim of this Research Topic is to gather a collection of basic Review articles and Original Research articles on neutrophil-mediated skin diseases in order to (i) provide an update on their genetic profile; (ii) promote improved understanding of the pathophysiological basis of these diseases; (iii) define new biomarkers predicting clinical outcome and response to treatment, and (iv) pave the way to a pathogenesis-driven therapeutic approach. In this Research Topic, we welcome the submission of Reviews, Mini-Reviews and Original Research articles that cover the following topics on neutrophil-mediated skin diseases:

1. Genetics.
2. Role of immune cells and cytokines.
3. Autoinflammation and neutrophil-mediated skin diseases.
4. New biomarkers.
5. Pyoderma gangrenosum and its syndromic forms.
6. Sweet’s syndrome.
7. Hidradenitis suppurativa.
8. Amicrobial pustulosis of the folds (APF).
9. Neutrophilic urticarial dermatosis.
10. Psoriasis vulgaris and pustular psoriasis.
11. Behçet syndrome.
12. New therapeutic approaches.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

28 September 2018 Manuscript
15 December 2018 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

28 September 2018 Manuscript
15 December 2018 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top
);