About this Research Topic
Mild traumatic brain injury (mTBI), otherwise known as concussion, is a common injury that typically results from exposure to improvised explosive devices (IEDs), falls, vehicular crashes, training, sports or other physical injury. This Research Topic seeks studies that examine topics related to mTBI/concussion, including but not limited to: clinical symptoms, neurocognitive and neurobehavioral assessment, neuroimaging, cross-sectional and longitudinal studies, sex differences, animal and human studies, pathophysiology, biomarkers, as well as co-morbid, pathological and systemic conditions related to neurological disease, neuropsychiatric conditions, neurometabolism, neuroinflammation and neurodegeneration. All article types are appropriate for submission, including, but not limited to, case reports, original investigations, hypothesis and theory, review articles, technology reports, empirical studies, clinical trials, summary articles of conferences and symposia, opinions and perspectives.
Past studies suggest a link between single and repetitive concussion and associated clinical symptoms, including sleep disturbance, headaches, and memory impairments. A greater number of total lifetime concussions has been linked to several neurological and neuropsychiatric disorders, such as increased insomnia, depression, emotional distress, and concussion symptom severity. It has been suggested that persistent clinical post-concussion symptoms might be due to or exacerbated by co-morbid mental health conditions. One study has also reported an increased suicide risk associated with a greater number of TBIs. Neurocognitive and neurobehavioral assessments have progressed in the area of developing sideline assessments for sports and blast injuries, giving more efficient diagnostic tools for mTBI/concussion, while most post-concussion neuroimaging studies reveal diffusion-related findings with respect to specific brain regions and tractography differences, but are primarily limited to pediatric, adolescent and sports-related concussion. There also exists a need to develop multiple biomarkers to elucidate the range of pathological and systemic conditions related to neurological disease, neurometabolism, neuroinflammation and neurodegeneration. Because of the high prevalence of mTBI/concussion history in the military and civilians, and the possibility that these injuries may cause suffering, disability, and have an adverse impact on quality of life, it is imperative that effects of mTBI/concussion be better understood.
Topic editor Dr Zetterberger is a co-founder of Brain Biomarker Solutions in Gothenburg AB, a GU Ventures-based platform company at the University of Gothenburg. All other topic editors declare no competing interests with regards to the Research Topic subject.
Keywords: concussion, mTBI, mental health, neurology, brain injury
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